DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPCAT and lpcat1

DIOPT Version :9

Sequence 1:	NP_001036265.1	Gene:	LPCAT / 31899	FlyBaseID:	FBgn0052699	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001037806.2	Gene:	lpcat1 / 555969	ZFINID:	ZDB-GENE-060503-915	Length:	517	Species:	Danio rerio

Alignment Length:	502	Identity:	186/502 - (37%)
Similarity:	281/502 - (55%)	Gaps:	38/502 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NYINPFVHRIEIDSHIEVAKIYVLTVLLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLT 112
            ::.|||||.:...: ::..||.|:||.|.|:|::.....::.||.||.:...|.:  :...:||:
Zfish    22 HFRNPFVHELRFTT-LQKLKIAVMTVTLFPVRLLFAAFMMLLAWPFAFVATVGRS--ENAVEPLS 83

  Fly   113 GWRKQMQYMTACGMRMVYTFGSFHYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVA 177
            .||..:.......||.::..|.||:|.:|||.|...|||||.:||||||.|:|.|..: ..|||.
Zfish    84 WWRWLVDLALKAIMRAMWFSGGFHWVRVKGRPALPSEAPILTMAPHSSYFDAIPVTMT-MASIVM 147

  Fly   178 KRETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALI 242
            |.|:.|||:.|.:|.:.:|::|.|.|.:||:.|:.:|..||.|..:|||::||.|||||||:.||
Zfish   148 KAESKDIPVWGTLIKFIRPVFVSRSDQDSRRKTVEEIKRRASSNGEWPQIMIFPEGTCTNRSCLI 212

  Fly   243 KFKPGAFYPGVPVQPVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDE 307
            .||||||.||||||||:|:|||:.||.:|||.|||..::||||:.|.:|..||||||.|||||:|
Zfish   213 AFKPGAFIPGVPVQPVVLRYPNELDTISWTWQGPGAFKILWLTLCQLHNFVEIEYLPTYTPSEEE 277

  Fly   308 VADANLYANNVREVMAKALGVPTSDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKLGL----- 367
            ..|..|:|:|||.:||||||:|..||||||..:......:::|....::|..|.:..|||
Zfish   278 KKDPALFASNVRRIMAKALGLPIIDYSFEDCQLAMAKGPLRLPKHTCLLEFARLVRLLGLKTKVT 342

  Fly   368 -----NESQRDAELCKGFLRLSNTDRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSF 427
                 .|:....:||        ..|||:..|.:.|...:... :..:|:|.:..  |.:.::.:
Zfish   343 DEVLREEASSARQLC--------GRRLDMEGFAQYLHQPMTEA-VQDIFSLFEEH--GMMDVREY 396

  Fly   428 LLC-SLFCK-LKNSDLLTFLRALIHLYSESSQQIDRESFVRLMRHAGGKLNEQKAQALFYALDTD 490
            ::. |:.|: .:..|  |...|.....::....|..:....:::.|.| :.:.....||.|:|:.
Zfish   397 VIALSVVCRPFRYLD--TVKLAFRMFEAQEDGAIVEDELTVILKTALG-VGDLAVSELFRAIDSQ 458

  Fly   491 NLGYVSFD---SFVELTEKQKSSYKFLYHK-SEHIRRPKAVVTTAEN 533
            :.|.::||   ||:|........|..|... |:|.|..    |::.|
Zfish   459 DKGKITFDDLCSFMEKCPDLVEQYHCLCESISQHSRES----TSSSN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	85/177 (48%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	121/211 (57%)
		EF-hand_8	455..507	CDD:290545	13/54 (24%)
lpcat1	NP_001037806.2	PlsC	52..>236	CDD:223282	87/186 (47%)
		LPLAT_LPCAT1-like	97..308	CDD:153253	121/211 (57%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	129..134		4/4 (100%)
		EF-hand_7	413..472	CDD:290234	12/59 (20%)
		EF-hand_8	424..475	CDD:290545	13/51 (25%)
		Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596102
Domainoid	1	1.000	138	1.000	Domainoid score	I4830
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9871
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2537
OMA	1	1.010	-	-		QHG58407
OrthoDB	1	1.010	-	-		D1266853at2759
OrthoFinder	1	1.000	-	-		FOG0001365
OrthoInspector	1	1.000	-	-		otm26059
orthoMCL	1	0.900	-	-		OOG6_100894
Panther	1	1.100	-	-	O	PTHR23063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4713
SonicParanoid	1	1.000	-	-		X772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800