DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPCAT and lpcat2

DIOPT Version :9

Sequence 1:	NP_001036265.1	Gene:	LPCAT / 31899	FlyBaseID:	FBgn0052699	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001018492.1	Gene:	lpcat2 / 553683	ZFINID:	ZDB-GENE-050522-229	Length:	529	Species:	Danio rerio

Alignment Length:	464	Identity:	177/464 - (38%)
Similarity:	269/464 - (57%)	Gaps:	28/464 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 INPFVHRIEIDSHIEVAKIYVLTVLLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLTGW 114
            ||||||.:.: |..::.|.::|.::|:|:|.:..:|.|:..|..:.|..:|.:|..: .:|:|||
Zfish    22 INPFVHDLSL-STADITKCFLLGIILVPLRAIFLLLVLLVMWPVSVIITFGQSLKGV-VEPMTGW 84

  Fly   115 RK--QMQYMTACGMRMVYTFGSFHYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVA 177
            |:  ..:.||..| || |.||....|.:||:.|:..|||||.||||||:.|:|..:.||.||.|:
Zfish    85 RRFLHRRVMTFLG-RM-YFFGMGFKVVVKGKKASTLEAPILAVAPHSSFFDAIACIESGLPSTVS 147

  Fly   178 KRETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALI 242
            :.|:.:.|:.|:.:...||:.|.|.||:||:|||.:|..||:|...||||:||.|||||||:.||
Zfish   148 RIESLEAPIFGRFLRCVQPVLVSRTDPDSRRNTIIEIERRAKSGGHWPQVLIFPEGTCTNRSCLI 212

  Fly   243 KFKPGAFYPGVPVQPVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDE 307
            .||.|.|.|||||||||::||||.||.||||.||...|||.||:.|.....|:|:||...|:|.|
Zfish   213 TFKQGGFVPGVPVQPVLIRYPNKLDTVTWTWQGPKSARLLLLTLCQLCTTVEVEFLPPQVPTEME 277

  Fly   308 VADANLYANNVREVMAKALGVPTSDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKLGLNESQR 372
            ......:|.:||.||||:|.:|.:|:::||..:|..|.::.:|....:||..:...||.|.....
Zfish   278 KKCPLKFAQSVRAVMAKSLKLPVTDHTYEDCRLMIAAGELTLPMEAGLVEFTKISRKLELKWDNV 342

  Fly   373 DAEL---------CKGFLRLSNTDRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSFL 428
            ..||         |||       .|:.:..|...|::.: :..|.:||||.|....||:..:.::
Zfish   343 KKELESFANIACSCKG-------GRITVEEFASFLKLPI-SPALQQLFALFDRNGDGTIDFREYV 399

  Fly   429 L-CSLFCKLKNSDLLTFLRALIHLYS-ESSQQIDRESFVRLMRHAGGKLNEQKAQALFYALDTDN 491
            : .::.|:..|::  ..::....|:. :....|.:|.|..|:|.|.| :.:....:||..:|.|.
Zfish   400 IGVTVLCRPANNE--EVIQTAFKLFDIDEDNCITQEEFSSLLRSALG-VCDLDVHSLFREIDADG 461

  Fly   492 LGYVSFDSF 500
            .|::::|.|
Zfish   462 SGHITYDEF 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	88/179 (49%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	109/211 (52%)
		EF-hand_8	455..507	CDD:290545	14/46 (30%)
lpcat2	NP_001018492.1	PlsC	49..297	CDD:223282	120/250 (48%)
		LPLAT_LPCAT1-like	98..309	CDD:153253	110/211 (52%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	128..133		3/4 (75%)
		EGTC motif	202..205		2/2 (100%)
		EFh	316..406	CDD:298682	22/97 (23%)
		EFh	378..440	CDD:238008	15/63 (24%)
		EF-hand_7	378..435	CDD:290234	13/58 (22%)
		EF-hand_7	415..473	CDD:290234	15/57 (26%)
		EFh	418..473	CDD:238008	15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596103
Domainoid	1	1.000	53	1.000	Domainoid score	I11371
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2537
OMA	1	1.010	-	-		QHG58407
OrthoDB	1	1.010	-	-		D1266853at2759
OrthoFinder	1	1.000	-	-		FOG0001365
OrthoInspector	1	1.000	-	-		otm26059
orthoMCL	1	0.900	-	-		OOG6_100894
Panther	1	1.100	-	-	LDO	PTHR23063
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770