Protein Alignment LPCAT and LPCAT2

DIOPT Version :9

• Sequence 1: NP_001036265.1
• Gene: LPCAT / 31899
• FlyBaseID: FBgn0052699
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_060309.2
• Gene: LPCAT2 / 54947
• HGNCID: 26032
• Length: 544
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 191/539 - (35%)
• Similarity: 298/539 - (55%)
• Gaps: 53/539 - (9%)

  Fly    14 VPPAGVVGNVADVGVAASLTKRDSEEDTWASKGYNYI-----NPFVHRIEIDSHIEVAKIYVLTV 73
            ||.|| |||   ||:...:..|.:          ::.     ||||.:.:|.|...| :|.:|.:
Human    14 VPGAG-VGN---VGLRPPMVPRQA----------SFFPPPVPNPFVQQTQIGSARRV-QIVLLGI 63

  Fly    74 LLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLTGWRKQMQYMTA---CGMRMVYTFGSF 135
            :||||||:...|.|:.||.||.|..  :...:....|:||||:::. .||   .|..|.::.|
Human    64 ILLPIRVLLVALILLLAWPFAAIST--VCCPEKLTHPITGWRRKIT-QTALKFLGRAMFFSMG-- 123

  Fly   136 HYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVAKRETADIPLLGKIINYAQPIYVQ 200
            ..|.:||:.|:..|||:.|.||||::.|.|..|.:|.||:|::.|.|.:||:|:::...||:.|.
Human   124 FIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVS 188

  Fly   201 REDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIKFKPGAFYPGVPVQPVLLKYPNK 265
            |.||:||:|||.:|:.|..|..:|||:::|.|||||||:.||.||||||.||||||||||:||||
Human   189 RVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNK 253

  Fly   266 YDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDEVADANLYANNVREVMAKALGVPT 330
            .||.||||.|...::|..||..|.:.:.|:|::||..|:::|..|..|:||.||.:||:|||:|.
Human   254 LDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPV 318

  Fly   331 SDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKL---------GLNESQRDAELCKGFLRLSNT 386
            :|:::||..:|..|..:.:|....:||..:...||         .|:|....|...||
Human   319 TDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKG------- 376

  Fly   387 DRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSFLL-CSLFCKLKNSDLLTFLRALIH 450
            .|:.|..|.:.|::.:.:. |.:||||.|....|::..:.::: .::.|...|::  ..::....
Human   377 GRIGIEEFAKYLKLPVSDV-LRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTE--EIIQVAFK 438

  Fly   451 LYS-ESSQQIDRESFVRLMRHAGGKLNEQKAQALFYAL-DTDNLGYVSFDSF-VELTEKQKSSYK 512
            |:. :....|..|.|..:::.:.| :.:.....||..: ..|::.|..|.|| ::..|..|....
Human   439 LFDVDEDGYITEEEFSTILQASLG-VPDLDVSGLFKEIAQGDSISYEEFKSFALKHPEYAKIFTT 502

  Fly   513 FLYHKSEHI-RRPKAVVTT 530
            :|..::.|: ..||.|.||
Human   503 YLDLQTCHVFSLPKEVQTT 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	85/180 (47%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	104/211 (49%)
		EF-hand_8	455..507	CDD:290545	12/53 (23%)
LPCAT2	NP_060309.2	LPLAT_LPCAT1-like	116..327	CDD:153253	105/212 (50%)
		HXXXXD motif. /evidence=ECO:0000250|UniProtKB:Q3TFD2	146..151		2/4 (50%)
		EGTC motif	220..223		2/2 (100%)
		EFh_PEF	374..494	CDD:330173	27/130 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..544		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159849
Domainoid	1	1.000	142	1.000	Domainoid score	I4689
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2491
Isobase	1	0.950	-	0	Normalized mean entropy	S3402
OMA	1	1.010	-	-		QHG58407
OrthoDB	1	1.010	-	-		D1266853at2759
OrthoFinder	1	1.000	-	-		FOG0001365
OrthoInspector	1	1.000	-	-		otm41037
orthoMCL	1	0.900	-	-		OOG6_100894
Panther	1	1.100	-	-	LDO	PTHR23063
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720