DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LPCAT and Lpcat4

DIOPT Version :9

Sequence 1:	NP_001036265.1	Gene:	LPCAT / 31899	FlyBaseID:	FBgn0052699	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001099964.1	Gene:	Lpcat4 / 296048	RGDID:	1311177	Length:	522	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	161/490 - (32%)
Similarity:	255/490 - (52%)	Gaps:	66/490 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPFVHRIEIDSHIEVAKIYVLTVLLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLTGWR 115
            |||||.:.: |.::..|..:|.|||.||||:...:.|...|.||.:.:.|:|.:.|: :|:||||
  Rat    23 NPFVHELHL-SGLQRVKFCLLGVLLAPIRVLLAFIVLFLLWPFAWLQVAGLTEEQLQ-EPITGWR 85

  Fly   116 KQMQYMTACGM-RMVYTFGSFHYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVAKR 179
            |.:.:....|: |:::....|..:.::|:.|:..|||:||.||||::.|.|:::....|.:|::.
  Rat    86 KTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKVVSRA 150

  Fly   180 ETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIKF 244
            |...:|::|.::.:.|.|.|.|.||.||:..:.::..||.|...||||:.|.||||:|:.||:||
  Rat   151 ENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKF 215

  Fly   245 KPGAFYPGVPVQPVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDEVA 309
            |||||..||||||||::|||..||.:|.|.|||||::||||.:|..:..::|:||||.||.:|..
  Rat   216 KPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYQPSPEESK 280

  Fly   310 DANLYANNVREVMAKALGVPTSDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKLGLNESQRDA 374
            |..||||||:.|||:|||:|.::..|...:.:.....:|:.....:.|:.:.::|.||:
  Rat   281 DPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGQLKVALEPQLWELGKVLQKAGLS------ 339

  Fly   375 ELCKGFLRLSNTDRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSFLLCSLFCKLKNS 439
               .||:.:.                             .:..||..:|.::|..     :|:.|
  Rat   340 ---PGFVDMG-----------------------------AEPGRSRMISQEAFAQ-----QLQLS 367

  Fly   440 DLLTFLRALIHLYSESSQQID-RESFVRLMRHAGGKLNEQKAQALF------YALDTDNLGYVSF 497
            |..|...|..:...::...:| |...:.|....||:..|:..:..|      .|.:.|.|.|
  Rat   368 DPQTVAGAFRYFQQDAKGLVDFRNVALALAALDGGRSLEELTRLAFELFAEEQAEEPDRLLY--- 429

  Fly   498 DSFVELTEKQKSSYKFLYHKSEHIRRPKAVVTTAE 532
                      |..:..:.|......||.|:...||
  Rat   430 ----------KDGFSTILHLLLGSPRPAAMTLHAE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	74/178 (42%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	98/212 (46%)
		EF-hand_8	455..507	CDD:290545	11/58 (19%)
Lpcat4	NP_001099964.1	LPLAT_LPCAT1-like	109..306	CDD:153253	95/196 (48%)
Lpcat4	NP_001099964.1	PlsC	109..295	CDD:223282	90/185 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353915
Domainoid	1	1.000	54	1.000	Domainoid score	I10930
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58407
OrthoDB	1	1.010	-	-		D1266853at2759
OrthoFinder	1	1.000	-	-		FOG0001365
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23063
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X772
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820