Protein Alignment LPCAT and GPAT4

DIOPT Version :10

• Sequence 1: NP_001036265.1
• Gene: LPCAT / 31899
• FlyBaseID: FBgn0052699
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_848934.1
• Gene: GPAT4 / 137964
• HGNCID: 20880
• Length: 456
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 79/316 - (25%)
• Similarity: 138/316 - (43%)
• Gaps: 49/316 - (15%)

  Fly    32 LTKRDSEE--DTW---ASKGYN--YINPFVHRIEIDSHIEVAKIYVLTVL-----LLPIRVVGCV 84
            :|||.|.|  ::|   :...||  ||:           :.:..::.|.||     |||:|:
Human   131 VTKRFSAEELESWNLLSRTNYNFQYIS-----------LRLTVLWGLGVLIRYCFLLPLRI---- 180

  Fly    85 LSLISAWMFACIGL--YGMT----LDDLKAKPLTGWRKQMQYMTACGMRMVYTFGSFHYVTMKGR 143
                 |..|..|.|  .|.|    |.:.:.|........:.....| :|.:....::|....:.|
Human   181 -----ALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRIC-VRALTAIITYHDRENRPR 239

  Fly   144 AATAKEAPILVVAPHSSYVDSILVVASGPPSIVAKRETADIPLLGKIINYAQP-IYVQREDPNSR 207
            ...      :.||.|:|.:|.|::.:.|..::|.:.....:.::.:.:..|.| ::.:|.:...|
Human   240 NGG------ICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDR 298

  Fly   208 QNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIKFKPGAFYPGVPVQPVLLKYPNKYDTFTWT 272
            ....:.:.:..:.....| ::||.||||.|.|:::.||.|:|..|..|.||.:||..::....|.
Human   299 HLVAKRLTEHVQDKSKLP-ILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWN 362

  Fly   273 WDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDEVADANLYANNVREVMAKALGV 328
            ....|::..|...||.:...|.:.|||..|...||  ||..:||.|:..:|:..|:
Human   363 SSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADE--DAVQFANRVKSAIARQGGL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	LPLAT_LPCAT1-like	126..338	CDD:153253	53/204 (26%)
		FRQ1	401..>505	CDD:444056
		EF-hand_8	455..507	CDD:404678
GPAT4	NP_848934.1	LPLAT_LPCAT1-like	218..427	CDD:153253	54/209 (26%)
		HXXXXD motif. /evidence=ECO:0000250|UniProtKB:Q9D517	248..253		2/4 (50%)