DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LPCAT and lpcat2

DIOPT Version :9

Sequence 1:	NP_001036265.1	Gene:	LPCAT / 31899	FlyBaseID:	FBgn0052699	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_012815924.2	Gene:	lpcat2 / 100124943	XenbaseID:	XB-GENE-946438	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	182/485 - (37%)
Similarity:	277/485 - (57%)	Gaps:	29/485 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPFVHRIEIDSHIEVAKIYVLTVLLLPIRVVGCVLSLISAWMFACIGLYGMTLDDLKAKPLTGWR 115
            |||||.|.: |.:...|:.:..:.|||:||:..::.|:.:|:.|.|..  ....:...|||.|||
Frog    58 NPFVHEINL-SPVNKLKMVLCGLFLLPLRVILFMIVLLVSWLVAAIAT--CCCPEKNEKPLEGWR 119

  Fly   116 KQMQYMTACGM--RMVYTFGSFHYVTMKGRAATAKEAPILVVAPHSSYVDSILVVASGPPSIVAK 178
            :::. .|..|.  |:::....|| |.::|:.||..:||||:||||||:.|:|.|:.||.||.|::
Frog   120 RKVT-QTLIGSLGRLLFFSMGFH-VRVEGKPATPSDAPILLVAPHSSFFDAIAVIVSGMPSSVSR 182

  Fly   179 RETADIPLLGKIINYAQPIYVQREDPNSRQNTIRDIVDRARSTDDWPQVVIFAEGTCTNRTALIK 243
            .|...:|:.|:|:...||:.|.|.||:||:|||.:|..||.|..:||||:||.|||||||:.||.
Frog   183 AENISVPIFGRILRALQPVLVSRVDPDSRKNTINEIKKRATSGGEWPQVLIFPEGTCTNRSCLIS 247

  Fly   244 FKPGAFYPGVPVQPVLLKYPNKYDTFTWTWDGPGVLRLLWLTMTQFYNRCEIEYLPVYTPSEDEV 308
            ||||||:|||||||:||:|||..||.||||.|..|.:||.||:.|......:|:||||.|||:|.
Frog   248 FKPGAFHPGVPVQPILLRYPNIQDTVTWTWQGFSVEKLLLLTLCQICTNVTVEFLPVYVPSEEEK 312

  Fly   309 ADANLYANNVREVMAKALGVPTSDYSFEDVIVMSRARDMKIPFPGDIVEIERTIEKLGLNESQRD 373
            .|..|||:|||..||:|||:|.:|:::||..:|..|.::.:|....:||..:..:||.|......
Frog   313 KDPFLYAHNVRHTMAQALGLPVTDHTYEDCRLMMTAGELTLPMETGLVEFTKISKKLNLKWDSIK 377

  Fly   374 AEL---------CKGFLRLSNTDRLDIITFGELLQVDLKNTDLHKLFALLDHRRSGTVSLKSFLL 429
            .:|         |||       .|:.|..|...|::.:.:. |.:||:|.|..:.||:..:.:::
Frog   378 KQLEVFASIAGSCKG-------GRIGIEEFANHLKLPVSDV-LRELFSLFDRNKDGTIDFREYVI 434

  Fly   430 -CSLFCKLKNSDLLTFLRALIHLYS-ESSQQIDRESFVRLMRHAGGKLNEQKAQALFYALDTDNL 492
             .::.|...|::  ..::....|:. :....|..:.|..|::.:.| :.:.....||..:|.||.
Frog   435 GVAILCNPANTE--ETIKMAFKLFDVDEDGSITEDEFSSLLQSSLG-VPDLDVSKLFRDMDADNS 496

  Fly   493 GYVSFDSFVELTEKQKSSYKFLYHKSEHIR 522
            |.:|::.|...:.......|......||.|
Frog   497 GKISYEEFRNFSLNHPEYAKLFTTYLEHQR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LPCAT	NP_001036265.1	PlsC	87..>265	CDD:223282	88/179 (49%)
		LPLAT_LPCAT1-like	126..338	CDD:153253	114/213 (54%)
		EF-hand_8	455..507	CDD:290545	12/51 (24%)
lpcat2	XP_012815924.2	LPLAT_LPCAT1-like	132..343	CDD:153253	115/211 (55%)
lpcat2	XP_012815924.2	FRQ1	359..509	CDD:227455	35/160 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2263
OMA	1	1.010	-	-		QHG58407
OrthoDB	1	1.010	-	-		D1266853at2759
OrthoFinder	1	1.000	-	-		FOG0001365
OrthoInspector	1	1.000	-	-		otm48239
Panther	1	1.100	-	-	LDO	PTHR23063
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X772
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080