DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31832 and TNR

DIOPT Version :9

Sequence 1:	NP_723894.2	Gene:	CG31832 / 318970	FlyBaseID:	FBgn0051832	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens

Alignment Length:	243	Identity:	85/243 - (34%)
Similarity:	126/243 - (51%)	Gaps:	34/243 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WTLLFEVGQSS-------------------PHTCPSGSPN-----GIHQLMLPEE--EPFQV-TQ 48
            :|:|.:..|.:                   |..|.....|     |::.:.|..|  :..|| ..
Human  1105 YTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGDTLSGVYPIFLNGELSQKLQVYCD 1169

  Fly    49 CKTTARDWIVIQRRLDGSVNFNQSWFSYKDGFGDPNGEFFIGLQKLYLMTREQPHELFIQLKHGP 113
            ..|....|||.|||.:|..:|.:.|..|:.|||:...||::||..::.:|.:..:||.:.::.|.
Human  1170 MTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQ 1234

  Fly   114 GATVYAHFDDFQVDSETELYKLERVGKYSGTAGDSLRYHINKRFSTFDRDNDESSKNCAAEHGGG 178
            .| .:|.:|.|.|:....|||| |:|.|:|||||||.||..:.|||.|||||.:..|||..:.|.
Human  1235 EA-AFASYDRFSVEDSRNLYKL-RIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGA 1297

  Fly   179 WWFHSCLSSSLNGLYFREGETGMLNGIHWGRWKFQ--SLTFVQIMIRP 224
            ||:.:|..::|||.|   ||:....||:|..||..  |:.||::.:||
Human  1298 WWYKNCHRTNLNGKY---GESRHSQGINWYHWKGHEFSIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31832	NP_723894.2	FReD	28..225	CDD:238040	80/207 (39%)
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248
		EGF_2	267..292	CDD:285248
		EGF_2	299..323	CDD:285248
		fn3	328..398	CDD:278470
		fn3	416..496	CDD:278470
		fn3	505..583	CDD:278470
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:278470
		fn3	776..855	CDD:278470
		fn3	865..944	CDD:278470
		fn3	954..1026	CDD:278470
		FN3	1042..1127	CDD:238020	3/21 (14%)
		FReD	1133..1342	CDD:238040	80/213 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910