DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31832 and FGB

DIOPT Version :9

Sequence 1:	NP_723894.2	Gene:	CG31832 / 318970	FlyBaseID:	FBgn0051832	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_005132.2	Gene:	FGB / 2244	HGNCID:	3662	Length:	491	Species:	Homo sapiens

Alignment Length:	233	Identity:	79/233 - (33%)
Similarity:	117/233 - (50%)	Gaps:	46/233 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LMLPEE--EPFQV-TQCKTTARDWIVIQRRLDGSVNFNQSWFSYKDGFGD-------------PN 84
            |:.|:.  :|::| ....|....|.|||.|.||||:|.:.|..||.|||:             |
Human   256 LIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLP- 319

  Fly    85 GEFFIGLQKLYLMTREQPHELFIQLKHGPGATVYAHFDDFQVDSETELYKLERVGKYSGTAGDSL 149
            ||:::|..|:..:||..|.||.|:::...|..|.||:..|.|.:|...|::. |.||.||||::|
Human   320 GEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQIS-VNKYRGTAGNAL 383

  Fly   150 --------------RYHINKRFSTFDRDND-----ESSKNCAAEHGGGWWFHSCLSSSLNGLYFR 195
                          ..|....|||:|||||     :..|.|:.|.|||||::.|.:::.||.|:.
Human   384 MDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYW 448

  Fly   196 EGE-------TGMLNGIHWGRWK--FQSLTFVQIMIRP 224
            .|:       .|..:|:.|..||  :.|:..:.:.|||
Human   449 GGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31832	NP_723894.2	FReD	28..225	CDD:238040	79/233 (34%)
FGB	NP_005132.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..75
		Beta-chain polymerization, binding distal domain of another fibrin	45..47
		Fib_alpha	92..234	CDD:312286
		FReD	237..486	CDD:294064	77/231 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4150
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860