DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and KIRREL3

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	354	Identity:	85/354 - (24%)
Similarity:	146/354 - (41%)	Gaps:	65/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SKGKHTRLDTQQT---AQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTI 115
            :|.|..|::..|.   :|:..|         .|.|| |:...:.|.:....|: |.|::  ....
Human    41 AKDKFRRMNEGQVYSFSQQPQD---------QVVVS-GQPVTLLCAIPEYDGF-VLWIK--DGLA 92

  Fly   116 LSIHHNVISQNSRISLTYNDHRSWYLHIK--EVEETDRGWYMCQVNTDPMRSRKGYLQVVVP--- 175
            |.:..::.|...  .|...:|.|...|:|  ..|..|...|.||.....:|||...|.|:||
Human    93 LGVGRDLSSYPQ--YLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDD 155

  Fly   176 PIIVEGLTSNDMVVREGQNISLVCKA-RGYPEPYVMWRREDGEEMLIGGEHVNVV--DGELLHIT 237
            |:|:.|..   :.:|.|..::|.|.| ...|...::|.|:.  |::.|..:...:  ||:...|
Human   156 PVILGGPV---ISLRAGDPLNLTCHADNAKPAASIIWLRKG--EVINGATYSKTLLRDGKRESI- 214

  Fly   238 KVSRLHMA--------AYLCVASN-GVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECH 293
             ||.|.::        :.:|.|:| .:|......|.:.:|.||::::..:.:.......|...|.
Human   215 -VSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCS 278

  Fly   294 TEAYPASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNS 358
            .:|.||...|...:|| .||.:.|  |:.|.||   ..||.:.:            ...|...|:
Human   279 AKANPAVTQYRWAKRG-QIIKEAS--GEVYRTT---VDYTYFSE------------PVSCEVTNA 325

  Fly   359 LGETDGNIKLD-----EMPTPTTAIISEM 382
            ||.|:.:..:|     .|.|...:::.::
Human   326 LGSTNLSRTVDVYFGPRMTTEPQSLLVDL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	24/93 (26%)
		IG_like	82..174	CDD:214653	25/93 (27%)
		IG_like	184..267	CDD:214653	21/94 (22%)
		IGc2	191..255	CDD:197706	18/75 (24%)
		IG_like	282..368	CDD:214653	22/85 (26%)
		Ig	288..367	CDD:143165	22/78 (28%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	26/105 (25%)
		IG_like	60..149	CDD:214653	25/103 (24%)
		I-set	156..249	CDD:254352	23/99 (23%)
		Ig2_KIRREL3-like	171..252	CDD:143236	19/84 (23%)
		Ig_2	260..337	CDD:290606	22/94 (23%)
		I-set	341..422	CDD:254352	2/14 (14%)
		IGc2	355..406	CDD:197706	85/354 (24%)
		Ig5_KIRREL3	424..521	CDD:143306
		IG_like	432..521	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810