DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and CD276

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens

Alignment Length:	440	Identity:	94/440 - (21%)
Similarity:	153/440 - (34%)	Gaps:	109/440 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VTVSVGRDALMACVVENLKGYKVA-----WVRVDTQTILSIHHNVISQNSRISLTYNDHRSWY-- 140
            |...||.||.:.|......|:.:|     |...||:.:  :|.....|:.  ...|.:..:.:
Human    38 VVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQL--VHSFAEGQDQ--GSAYANRTALFPD 98

  Fly   141 --------LHIKEVEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISL 197
                    |.::.|...|.|.:.|.|:.....|....|||..|..........:..:|.|..:::
Human    99 LLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTI 163

  Fly   198 VCKA-RGYPEPYVMWRREDGEEMLIGGEHVNVVDGE------LLHITKVSRLHMAA---YLCVAS 252
            .|.: :||||..|.|  :||:.:.:.|   ||...:      |..:..:.|:.:.|   |.|:..
Human   164 TCSSYQGYPEAEVFW--QDGQGVPLTG---NVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVR 223

  Fly   253 NGVPPSISKRVHLRVQFPPMLS--------IPNQLEGAYLGQDVILECHTEAYP----ASIN-YW 304
            |   |.:.:..|..|...|..|        :|.....|.:|.|..|.|.....|    |.:| .|
Human   224 N---PVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIW 285

  Fly   305 -TTERGDMIISDTS--RAGDKYETTSTV------SGYTKYMKLKIRAVGPNDFGTYRC-VAKNSL 359
             .|:...::.|.|.  ..|..|...:.:      .|..   .|:::.|...|.|::.| |:....
Human   286 QLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNA---SLRLQRVRVADEGSFTCFVSIRDF 347

  Fly   360 GETDGNIKL---------------DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYG 409
            |....::::               |..|..|..|...      ||.|       :..|...
Human   348 GSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCS------SYRG-------YPEAEVF---- 395

  Fly   410 VEEWRDGAQGNNAGNNGDNNQTPVRNPPGAFHNSAGSLAQHNLLAKIMLG 459
               |:|| ||.....|...:|         ..|..|....|::| :::||
Human   396 ---WQDG-QGVPLTGNVTTSQ---------MANEQGLFDVHSVL-RVVLG 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/103 (21%)
		IG_like	82..174	CDD:214653	24/105 (23%)
		IG_like	184..267	CDD:214653	22/92 (24%)
		IGc2	191..255	CDD:197706	19/73 (26%)
		IG_like	282..368	CDD:214653	22/100 (22%)
		Ig	288..367	CDD:143165	19/93 (20%)
CD276	NP_001019907.1	IG_like	37..138	CDD:214653	22/103 (21%)
		Ig	43..139	CDD:299845	21/99 (21%)
		Ig	148..231	CDD:299845	21/90 (23%)
		IG_like	156..237	CDD:214653	23/88 (26%)
		IG_like	255..356	CDD:214653	22/103 (21%)
		Ig	261..357	CDD:299845	21/98 (21%)
		Ig	366..449	CDD:299845	21/97 (22%)
		IG_like	374..456	CDD:214653	20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910