DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and VTCN1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_011540445.2	Gene:	VTCN1 / 79679	HGNCID:	28873	Length:	332	Species:	Homo sapiens

Alignment Length:	301	Identity:	53/301 - (17%)
Similarity:	107/301 - (35%)	Gaps:	100/301 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFRLQAEFNVRQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIA 81
            |.|...:.::  ::|.||...|:.:::       .....|:|:                    |.
Human    53 RIRRSRKHSI--ISIIIILAGAIALII-------GFGISGRHS--------------------IT 88

  Fly    82 NVTV----SVGRDALMACVVE---NLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHR-- 137
            ..||    ::|.|.:::|..|   .|....:.|::   :.:|.:.|..  :..:..|:..|..
Human    89 VTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLK---EGVLGLVHEF--KEGKDELSEQDEMFR 148

  Fly   138 -------------SWYLHIKEVEETDRGWYMCQVNTDPMRSRKGYLQV-------VVPPIIVEGL 182
                         :..|.:|.|:.||.|.|.|.:.|.   ..||...:       .:|.:.|:..
Human   149 GRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITS---KGKGNANLEYKTGAFSMPEVNVDYN 210

  Fly   183 TSNDMVVREGQNISLVCKA-RGYPEPYVMWRRE----------DGEEMLIGGEHVNVVDGELLHI 236
            .|::         :|.|:| |.:|:|.|:|..:          ......:..|:|.:....:|:.
Human   211 ASSE---------TLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYN 266

  Fly   237 TKVSRLHMAAYLCVASNGVPPS----------ISKRVHLRV 267
            ..::.    .|.|:..|.:..:          |.:|.||::
Human   267 VTINN----TYSCMIENDIAKATGDIKVTESEIKRRSHLQL 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	24/113 (21%)
		IG_like	82..174	CDD:214653	23/120 (19%)
		IG_like	184..267	CDD:214653	19/103 (18%)
		IGc2	191..255	CDD:197706	14/74 (19%)
		IG_like	282..368	CDD:214653
		Ig	288..367	CDD:143165
VTCN1	XP_011540445.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910