DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and ush2a

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	525	Identity:	89/525 - (16%)
Similarity:	163/525 - (31%)	Gaps:	171/525 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTD 161
            |.|....:::|...|:....::.:.::.....|.::::.|....:|..:...:....|..|:.|.
Zfish  1078 VLNSTTIELSWRTPDSPNSNALMYTLLRDTQIIHVSHSQHPFGTMHFIDTALSPYTLYSYQLITS 1142

  Fly   162 PMRSRKGYLQVVVPPIIVEGLTSNDMV-------VREGQNISLVCKARGYP--------EP---- 207
            .:||.                ||:.:|       |.|.:.:.|....|..|        ||
Zfish  1143 NIRSN----------------TSSSVVTLRTLSAVPEQEELQLTLVGRAKPNSASFNWTEPLNTT 1191

  Fly   208 -----YVMWRRED--GEEML-IGGEHVNVVDGELLHITKVSRLHMAAYLC------------VAS 252
                 |.:...:|  ||:.: ..|........||...|   |.:.:...|            |.:
Zfish  1192 GPIDNYTLSSIQDLSGEKRIYYTGLQTEATAEELQPFT---RYNFSLKACTDGGCARSESLVVQT 1253

  Fly   253 NGVPP--------SISKRVHLRVQF-PPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTER 308
            ..:||        :......|:|.: ||:|  ||   |..:..::.::...|....:.:|.|.:|
Zfish  1254 AQIPPEQQPAPKITTLGSSQLKVDWEPPVL--PN---GIIIRYELFMQLLNELQRNASSYGTEQR 1313

  Fly   309 ----------GDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGT------------- 350
                      ...:.|....|....|:|..||....:...:.|.:..|..|:
Zfish  1314 VFLSSGWLNPRPSLSSANENALTPPESTVVVSNLQPFSTYRFRVLTVNMAGSVLSDWAVGRTAEG 1378

  Fly   351 ---------YRCVAKNSL-------------GETDG---NIKLDEMPTP-----TTAIISEMSLL 385
                     ...|:.:||             ||...   |:..::|..|     .|.::...|..
Zfish  1379 VPEYMAPPQVSAVSSSSLRVSWETPRDKDVRGEVTEYRVNLHQEQMSNPYAPPIVTQVLYSGSAQ 1443

  Fly   386 NRSYDGKRRHRNKFDSANALPDYGVEEW--------RDGAQGNNAGNNGDNNQTP---------- 432
            ..||           :|..|..|  ||:        |.|...::..:.......|
Zfish  1444 EHSY-----------TAGGLKAY--EEYSFTVTVCNRQGCVSSSPASGRTLPSAPAGLRAPGLRP 1495

  Fly   433 ---------------VRNPPGAFHNSAGSLAQHNLLAKIMLGIKTQSFGIFKRLSSSLPLAAGQS 482
                           :..||..:|.....::..:...:::.|.:....|.|:..|::||:.|..:
Zfish  1496 LNMTAMNVFWDAPAELNGPPPLYHVERTDVSLSDAQGQVIRGRRFTGSGFFRFPSATLPVNADFT 1560

  Fly   483 FLWLS 487
            .|.||
Zfish  1561 GLQLS 1565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	12/74 (16%)
		IG_like	82..174	CDD:214653	12/76 (16%)
		IG_like	184..267	CDD:214653	23/129 (18%)
		IGc2	191..255	CDD:197706	17/95 (18%)
		IG_like	282..368	CDD:214653	19/133 (14%)
		Ig	288..367	CDD:143165	19/126 (15%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020	14/78 (18%)
		FN3	1264..1375	CDD:238020	21/115 (18%)
		FN3	1386..1469	CDD:214495	18/95 (19%)
		LamG	1537..1699	CDD:238058	10/29 (34%)
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900