DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and KIRREL1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	367	Identity:	87/367 - (23%)
Similarity:	152/367 - (41%)	Gaps:	79/367 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDT 112
            ||::..|:|..|               ||::..|:.||..|:.|::.||:.|..|. |.|    |
Human    10 TLSDTFSQGTQT---------------RFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQW----T 54

  Fly   113 QTILSIHHNVISQNSRISLTYN-----DHRSWYLHIKEVEETDRGWYMCQVNTDPMRSRKGYLQV 172
            :..|::.   :.|..:....|.     |...:.|.|.:.|.:|...|.||.....:|||:..|.|
Human    55 KDGLALG---MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTV 116

  Fly   173 VVPP--IIVEGLTSNDMVVREGQNISLVCKA-RGYPEPYVMWRREDGE--------EMLIGGEHV 226
            ::||  ..::|  ...::::.|...:|.|:| ...|...::|.|:..:        |:|..|:..
Human   117 LIPPEDTRIDG--GPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRE 179

  Fly   227 NVVDGELLHIT--KVSRLHMAAYLCVASN-GVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDV 288
            ..|...|::.|  .:.|:    :.|.:.| .:|......:.|.|..||.:::..:.:....|:.|
Human   180 TTVSQLLINPTDLDIGRV----FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240

  Fly   289 ILECHTEAYPASINY-WTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYR 352
            :..|...|.|..:.| |.  :|..:|.|...:  :|||....|.:|:.:.
Human   241 VFTCQATANPEILGYRWA--KGGFLIEDAHES--RYETNVDYSFFTEPVS--------------- 286

  Fly   353 CVAKNSLGETD----------GNIKLDEMPTPTTAIISEMSL 384
            |...|.:|.|:          ..|.:|..|| ||.|.|:::|
Human   287 CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT-TTDIGSDVTL 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	27/96 (28%)
		IG_like	82..174	CDD:214653	27/96 (28%)
		IG_like	184..267	CDD:214653	18/94 (19%)
		IGc2	191..255	CDD:197706	16/75 (21%)
		IG_like	282..368	CDD:214653	20/96 (21%)
		Ig	288..367	CDD:143165	18/89 (20%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	29/101 (29%)
		Ig	25..116	CDD:299845	27/98 (28%)
		Ig2_KIRREL3-like	138..219	CDD:143236	17/84 (20%)
		I-set	223..304	CDD:254352	20/99 (20%)
		Ig_2	227..305	CDD:290606	19/96 (20%)
		Ig_2	311..405	CDD:290606	8/18 (44%)
		IG_like	314..405	CDD:214653	7/15 (47%)
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810