DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and SDK2

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	607	Identity:	119/607 - (19%)
Similarity:	213/607 - (35%)	Gaps:	163/607 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQ------EDSDFPRFAEPIA----- 81
            ::|||:..|  :.:|.|..|.......:..:.:....:|:|      |:...|  |:|||
Human   159 RIAITLENT--LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGP--ADPIAPTIII 219

  Fly    82 ---NVTVSVG-RDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLT--YNDHRSWY 140
               |.:|..| .:..:.||             .:.:.::.:|  :|.:...:.|:  .:||.. .
Human   220 PPKNTSVVAGTSEVTLECV-------------ANARPLIKLH--IIWKKDGVLLSGGISDHNR-R 268

  Fly   141 LHIKEVEETDRGWYMCQV----NTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKA 201
            |.|.....:|.|:|.|:.    ::.|...|..||.|:.||..|:. ....:.....:.:.:.|:|
Human   269 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE-PERHITAEMEKVVDIPCQA 332

  Fly   202 RGYPEPYVMWRREDGEEMLIGGEHVNVVDGELLHITKVSRLHM----------------AAYLCV 250
            :|.|.|.:.|.:                |..::.:.|::|...                ..:.|.
Human   333 KGVPPPSITWYK----------------DAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCF 381

  Fly   251 ASNGVPPSISKRVHLRVQFPPMLSI----PNQLEG-----AYLGQDVILECHTEAYPASINYWTT 306
            |.|...         .||....|::    ||...|     ...|..|:|.|.|...|.....|
Human   382 ARNAAG---------EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITW-- 435

  Fly   307 ERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKL--- 368
            ::|:.|::..|....::  |...||     .|.|.....:|.|||.|:|.||.|..:.:..|
Human   436 QKGERILASGSVQLPRF--TPLESG-----SLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493

  Fly   369 ----DEMPTPTTAII--SEMSLL-NRSYD----------------GKRRH-RNKFDSANAL---- 405
                ...|....::|  ::.|:: ..::|                |...| |.:.|...:|
Human   494 ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQ 558

  Fly   406 ---PDYGVEEWRDGAQGNNAGNNGDNNQTPVRNPPGAFHNSAGSLAQHNLLAKIMLGIKTQSFGI 467
               .|.|....|..:.|   ||:..:....||..|.|..:...:|:.          ::.::..:
Human   559 TWSGDIGTYTCRVISAG---GNDSRSAHLRVRQLPHAPEHPVATLST----------VERRAINL 610

  Fly   468 --FKRLSSSLPLAAGQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVVNNDTAAECWETRSHCV 530
              .|....:.||     ..::..:|..:||  |.:......|.:....|.....|..::.|...|
Human   611 TWTKPFDGNSPL-----IRYILEMSENNAP--WTVLLASVDPKATSVTVKGLVPARSYQFRLCAV 668

  Fly   531 SESNNNNNSRITQR------PP 546
            ::......|:.|:|      ||
Human   669 NDVGKGQFSKDTERVSLPEEPP 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/106 (21%)
		IG_like	82..174	CDD:214653	21/98 (21%)
		IG_like	184..267	CDD:214653	12/98 (12%)
		IGc2	191..255	CDD:197706	12/79 (15%)
		IG_like	282..368	CDD:214653	24/85 (28%)
		Ig	288..367	CDD:143165	23/78 (29%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	9/45 (20%)
		Ig	132..210	CDD:299845	11/54 (20%)
		IG_like	222..304	CDD:214653	20/97 (21%)
		IGc2	233..286	CDD:197706	13/68 (19%)
		I-set	308..397	CDD:254352	17/114 (15%)
		Ig	326..394	CDD:143165	14/92 (15%)
		I-set	402..492	CDD:254352	28/98 (29%)
		Ig	416..492	CDD:299845	25/84 (30%)
		Ig	502..586	CDD:299845	14/86 (16%)
		IG_like	502..586	CDD:214653	14/86 (16%)
		FN3	590..681	CDD:238020	16/107 (15%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810