DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-kappa and OPCML

DIOPT Version :9

Sequence 1:NP_723828.1 Gene:DIP-kappa / 318958 FlyBaseID:FBgn0051814 Length:672 Species:Drosophila melanogaster
Sequence 2:NP_001306032.1 Gene:OPCML / 4978 HGNCID:8143 Length:354 Species:Homo sapiens


Alignment Length:318 Identity:100/318 - (31%)
Similarity:152/318 - (47%) Gaps:41/318 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 DSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYN 134
            |:.||:..:   ||||..|..|.:.|.::: :..:|||  ::..|||...::..|.:.|:.:..|
Human    35 DATFPKAMD---NVTVRQGESATLRCTIDD-RVTRVAW--LNRSTILYAGNDKWSIDPRVIILVN 93

  Fly   135 DHRSWYLHIKEVEETDRGWYMCQVNTD--PMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISL 197
            ....:.:.|:.|:..|.|.|.|.|.||  |..||. :|.|.|||.|:.  .|:|:.|.||.:::|
Human    94 TPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRV-HLIVQVPPQIMN--ISSDITVNEGSSVTL 155

  Fly   198 VCKARGYPEPYVMWRREDGEEMLIGGEHVNVVDG-------ELLHITKVSRLHMAAYLCVASNGV 255
            :|.|.|.|||.|.||            |::|.:|       |.|.|:.:.|.....|.|.|.|.|
Human   156 LCLAIGRPEPTVTWR------------HLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDV 208

  Fly   256 PPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAG 320
            .....::|.:.|.:||.:|.... .|..:||..||.|...|.|.:...|..|...:.   |...|
Human   209 AAPDVRKVKITVNYPPYISKAKN-TGVSVGQKGILSCEASAVPMAEFQWFKEETRLA---TGLDG 269

  Fly   321 DKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPTTAI 378
            .:.|....:|..|.:      .|...|:|.|.|||.|.||.|:.:|.|.|: :|::|:
Human   270 MRIENKGRMSTLTFF------NVSEKDYGNYTCVATNKLGNTNASITLYEI-SPSSAV 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-kappaNP_723828.1 Ig 80..172 CDD:299845 29/93 (31%)
IG_like 82..174 CDD:214653 30/93 (32%)
IG_like 184..267 CDD:214653 28/89 (31%)
IGc2 191..255 CDD:197706 23/70 (33%)
IG_like 282..368 CDD:214653 26/85 (31%)
Ig 288..367 CDD:143165 23/78 (29%)
OPCMLNP_001306032.1 Ig 44..132 CDD:416386 29/91 (32%)
Ig strand A' 44..49 CDD:409353 4/4 (100%)
Ig strand B 51..59 CDD:409353 2/7 (29%)
CDR1 59..63 CDD:409353 0/4 (0%)
FR2 64..70 CDD:409353 3/7 (43%)
Ig strand C 64..70 CDD:409353 3/7 (43%)
CDR2 71..83 CDD:409353 3/11 (27%)
Ig strand C' 72..76 CDD:409353 2/3 (67%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 8/33 (24%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 2/3 (67%)
Ig strand G 123..132 CDD:409353 4/9 (44%)
FR4 125..132 CDD:409353 3/7 (43%)
Ig_3 135..206 CDD:404760 28/84 (33%)
Ig strand A 135..138 CDD:409353 2/2 (100%)
Ig strand A' 144..148 CDD:409353 1/3 (33%)
Ig strand B 151..160 CDD:409353 2/8 (25%)
Ig strand C 165..170 CDD:409353 2/4 (50%)
Ig strand C' 171..174 CDD:409353 1/2 (50%)
Ig strand F 198..206 CDD:409353 3/7 (43%)
Ig 224..312 CDD:416386 29/97 (30%)
putative Ig strand A 224..230 CDD:409353 2/5 (40%)
Ig strand B 240..244 CDD:409353 2/3 (67%)
Ig strand C 253..257 CDD:409353 0/3 (0%)
Ig strand E 279..283 CDD:409353 1/3 (33%)
Ig strand F 293..298 CDD:409353 2/4 (50%)
Ig strand G 306..309 CDD:409353 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143455
Domainoid 1 1.000 45 1.000 Domainoid score I12195
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8497
orthoMCL 1 0.900 - - OOG6_104123
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3058
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.680

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