DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and NCAM1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	450	Identity:	98/450 - (21%)
Similarity:	166/450 - (36%)	Gaps:	103/450 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GRDALMACVVENLKGYKVAWVRVDTQTIL--SIHHNVISQNSRISLTYNDHRSWYLHIKEVEETD 150
            |.||::.|.|.:.....:.|.......||  .:...|:|.|             ||.|:.:::||
Human   132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN-------------YLQIRGIKKTD 183

  Fly   151 RGWYMC--------QVNTDPMRSRKGYLQVV--VPPIIVEGLTSNDMVVREGQNISLVCKARGYP 205
            .|.|.|        ::|...       :||:  |||.|.......:.....||:::|||.|.|:|
Human   184 EGTYRCEGRILARGEINFKD-------IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241

  Fly   206 EPYVMWRREDGEEMLIGGEHVNVV---DGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRV 267
            ||.:.|.: |||::....:....:   |...|.|.||.:...|.|:|:|.|..... ...:||:|
Human   242 EPTMSWTK-DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQ-DATIHLKV 304

  Fly   268 QFPPMLSIPNQLEGAYLGQDVILECHTEAYP-ASINYWTTERGDMIISDTSRAG----------- 320
            ...|.::.........|.:.|.|.|.....| .||.:.|:.|.   ||...:|.
Human   305 FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN---ISSEEKASWTRPEKQEVHA 366

  Fly   321 -------------------DKYETTS---TVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETD 363
                               ..:||..   .|..:.:...|.::::...|.|.|.|.|.|::|:..
Human   367 PWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 431

  Fly   364 GNIKLD-----EMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVEEWRDG--AQGNN 421
            .::.|:     ::..|......|.:.:|.:.:           ..|.|...:..:|||  ...:|
Human   432 QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE-----------VFAYPSATISWFRDGQLLPSSN 485

  Fly   422 AGNNGDNNQTPVRNPPGAFH-----NSAGSLAQHNLLAKIMLGIKTQSFGIFKRLSSSLP 476
            ..|      ..:.|.|.|.:     :|......:|..|...:|.::..|.:.:..:.|.|
Human   486 YSN------IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	20/93 (22%)
		IG_like	82..174	CDD:214653	22/97 (23%)
		IG_like	184..267	CDD:214653	26/85 (31%)
		IGc2	191..255	CDD:197706	24/66 (36%)
		IG_like	282..368	CDD:214653	23/119 (19%)
		Ig	288..367	CDD:143165	22/112 (20%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	18/70 (26%)
		Ig	211..307	CDD:325142	30/97 (31%)
		Ig	306..438	CDD:325142	25/134 (19%)
		Ig_3	447..519	CDD:316449	16/88 (18%)
		FN3	534..631	CDD:238020	1/5 (20%)
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910