DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and LSAMP

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	313	Identity:	105/313 - (33%)
Similarity:	149/313 - (47%)	Gaps:	42/313 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDH 136
            ||.|..:   |:||..|..|::.||||: |..||||  ::...|:...|:..|.:.|:.|.....
Human    33 DFNRGTD---NITVRQGDTAILRCVVED-KNSKVAW--LNRSGIIFAGHDKWSLDPRVELEKRHS 91

  Fly   137 RSWYLHIKEVEETDRGWYMCQVNT--DPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVC 199
            ..:.|.|::|:..|.|.|.|.|.|  :|..|:. ||.|.|||.|..  .|:|:.|.||.|::|||
Human    92 LEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQV-YLIVQVPPKISN--ISSDVTVNEGSNVTLVC 153

  Fly   200 KARGYPEPYVMWR------RE-DGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPP 257
            .|.|.|||.:.||      || :|||             |.|.|..::|.....|.|.|:|.|..
Human   154 MANGRPEPVITWRHLTPTGREFEGEE-------------EYLEILGITREQSGKYECKAANEVSS 205

  Fly   258 SISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDK 322
            :..|:|.:.|.:||.::.....| |..|:...|:|...|.||....|  .|.|..|:  |..|.:
Human   206 ADVKQVKVTVNYPPTITESKSNE-ATTGRQASLKCEASAVPAPDFEW--YRDDTRIN--SANGLE 265

  Fly   323 YETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPT 375
            .::|...|..|      :..|....:|.|.|||.|.||.|:.::.|.:...||
Human   266 IKSTEGQSSLT------VTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPT 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	32/93 (34%)
		IG_like	82..174	CDD:214653	33/93 (35%)
		IG_like	184..267	CDD:214653	32/89 (36%)
		IGc2	191..255	CDD:197706	26/70 (37%)
		IG_like	282..368	CDD:214653	26/85 (31%)
		Ig	288..367	CDD:143165	24/78 (31%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	32/96 (33%)
		Ig	132..215	CDD:386229	34/97 (35%)
		Ig_3	219..294	CDD:372822	24/85 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143415
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780