DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-kappa and IGLON5

DIOPT Version :9

Sequence 1:NP_723828.1 Gene:DIP-kappa / 318958 FlyBaseID:FBgn0051814 Length:672 Species:Drosophila melanogaster
Sequence 2:NP_001094842.1 Gene:IGLON5 / 402665 HGNCID:34550 Length:336 Species:Homo sapiens


Alignment Length:391 Identity:111/391 - (28%)
Similarity:164/391 - (41%) Gaps:73/391 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LPRPHTRRRFRLQAEFNVRQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDF 73
            :|.|....|.||        ||...:|..||.             |:|    |.:|..       
Human     1 MPPPAPGARLRL--------LAAAALAGLAVI-------------SRG----LLSQSL------- 33

  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138
             .|..|..|.||..|.:|.::|.::. ...:|||  ::...||...::..:.:.|:.|..|....
Human    34 -EFNSPADNYTVCEGDNATLSCFIDE-HVTRVAW--LNRSNILYAGNDRWTSDPRVRLLINTPEE 94

  Fly   139 WYLHIKEVEETDRGWYMCQVNT--DPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKA 201
            :.:.|.||...|.|.|.|...|  .|..::. ||.|.||..||.  .|:.:.|.||.|::|:|.|
Human    95 FSILITEVGLGDEGLYTCSFQTRHQPYTTQV-YLIVHVPARIVN--ISSPVTVNEGGNVNLLCLA 156

  Fly   202 RGYPEPYVMWRR-EDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGV--PPSISKRV 263
            .|.|||.|.||: .||          ...:||:|.|:.:.|.....|.||..|||  .|. |:||
Human   157 VGRPEPTVTWRQLRDG----------FTSEGEILEISDIQRGQAGEYECVTHNGVNSAPD-SRRV 210

  Fly   264 HLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTST 328
            .:.|.:||.::.......| ||:..:|.|...|.|.:...|  .:.|.::|..:..|.|.:|..|
Human   211 LVTVNYPPTITDVTSARTA-LGRAALLRCEAMAVPPADFQW--YKDDRLLSSGTAEGLKVQTERT 272

  Fly   329 VSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKL-------DEMPTP--TTAIISEMSL 384
            .|      .|....|....:|.|.|.|.|.||.:..:::|       :..|.|  ..|::|.:..
Human   273 RS------MLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGW 331

  Fly   385 L 385
            |
Human   332 L 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-kappaNP_723828.1 Ig 80..172 CDD:299845 25/93 (27%)
IG_like 82..174 CDD:214653 26/93 (28%)
IG_like 184..267 CDD:214653 32/85 (38%)
IGc2 191..255 CDD:197706 24/64 (38%)
IG_like 282..368 CDD:214653 24/85 (28%)
Ig 288..367 CDD:143165 21/78 (27%)
IGLON5NP_001094842.1 Ig 41..129 CDD:416386 25/91 (27%)
Ig strand A' 41..46 CDD:409353 3/4 (75%)
Ig strand B 48..56 CDD:409353 2/7 (29%)
CDR1 56..60 CDD:409353 0/4 (0%)
FR2 61..68 CDD:409353 3/8 (38%)
Ig strand C 61..67 CDD:409353 3/7 (43%)
CDR2 69..79 CDD:409353 2/9 (22%)
Ig strand C' 71..74 CDD:409353 2/2 (100%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 10/34 (29%)
Ig strand D 84..91 CDD:409353 2/6 (33%)
Ig strand E 94..100 CDD:409353 0/5 (0%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 1/3 (33%)
Ig strand G 120..129 CDD:409353 3/9 (33%)
FR4 122..129 CDD:409353 2/7 (29%)
Ig_3 134..199 CDD:404760 27/76 (36%)
Ig strand B 148..157 CDD:409353 3/8 (38%)
Ig strand C 162..170 CDD:409353 4/7 (57%)
Ig strand F 191..199 CDD:409353 3/7 (43%)
Ig strand G 202..212 CDD:409353 4/10 (40%)
Ig_3 217..295 CDD:404760 23/86 (27%)
putative Ig strand A 218..224 CDD:409353 1/5 (20%)
Ig strand B 234..238 CDD:409353 1/3 (33%)
Ig strand C 247..251 CDD:409353 1/5 (20%)
Ig strand E 274..278 CDD:409353 2/9 (22%)
Ig strand F 288..293 CDD:409353 2/4 (50%)
Ig strand G 301..304 CDD:409353 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143465
Domainoid 1 1.000 45 1.000 Domainoid score I12195
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8497
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.750

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