DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and robo1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	86/324 - (26%)
Similarity:	127/324 - (39%)	Gaps:	52/324 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138
            |.|.:...:..:..|:.|...|.|......||.|.:.:        .|:....:||   .:|.:|
  Fly   255 PYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEE--------GNIPVSRARI---LHDEKS 308

  Fly   139 WYLHIKEVEETDRGWYMCQV-NTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKAR 202
              |.|..:..||.|.|:|:. |.....|.:..|.|..||...: ..||..|...|. :.|.|.|.
  Fly   309 --LEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTK-RPSNKKVGLNGV-VQLPCMAS 369

  Fly   203 GYPEPYVMWRREDGEEMLI-----GGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKR 262
            |.|.|.|.|.:|....::.     |.:|| ..|| .|.||.|.:.....|:|.|.: |..|.:.|
  Fly   370 GNPPPSVFWTKEGVSTLMFPNSSHGRQHV-AADG-TLQITDVRQEDEGYYVCSAFS-VVDSSTVR 431

  Fly   263 VHLRVQF-----PPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDK 322
            |.|:|..     ||::.|....:....|....|.|.....|:....|..: |..:     :||::
  Fly   432 VFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHD-GHAV-----QAGNR 490

  Fly   323 YETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETD----------GNIKLDEMPTPTT 376
            |   |.:.|    ..|::..:..:|.|||.|.|....|||.          |:..|.....|:|
  Fly   491 Y---SIIQG----SSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPST 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/92 (24%)
		IG_like	82..174	CDD:214653	23/92 (25%)
		IG_like	184..267	CDD:214653	30/87 (34%)
		IGc2	191..255	CDD:197706	22/68 (32%)
		IG_like	282..368	CDD:214653	22/95 (23%)
		Ig	288..367	CDD:143165	21/88 (24%)
robo1	NP_476899.1	Ig	56..151	CDD:299845
		I-set	56..150	CDD:254352
		I-set	157..251	CDD:254352
		Ig2_Robo	159..251	CDD:143201
		I-set	255..341	CDD:254352	24/98 (24%)
		Ig3_Robo	272..341	CDD:143202	21/81 (26%)
		IG_like	351..436	CDD:214653	30/88 (34%)
		Ig	362..444	CDD:299845	27/84 (32%)
		I-set	445..531	CDD:254352	23/98 (23%)
		IGc2	459..521	CDD:197706	18/74 (24%)
		FN3	549..637	CDD:238020
		FN3	673..762	CDD:238020
		fn3	770..855	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010