DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and VSIG1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_005262184.1	Gene:	VSIG1 / 340547	HGNCID:	28675	Length:	449	Species:	Homo sapiens

Alignment Length:	460	Identity:	99/460 - (21%)
Similarity:	159/460 - (34%)	Gaps:	133/460 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQAEFNVRQLAI-----TIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDF-PRFAE 78
            |..:.:|.|:.|     .:...:.||::...|.|:|           ..:|.:.:.|.| .:..|
Human    15 LAGQVSVVQVTIPDGFVNVTVGSNVTLICIYTTTVA-----------SREQLSIQWSFFHKKEME 68

  Fly    79 PIAN-----------------VTVSVGRDALMACV--------------VENLKGYKVAWVRVD- 111
            ||::                 :.::..|||...|.              ||.:||      .:|
Human    69 PISHSSCLSTEGMEEKAVSQCLKMTHARDARGRCSWTSESPWEEGKWPDVEAVKG------TLDG 127

  Fly   112 TQTILSIHHN------VISQ-NSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTDP--MRSRK 167
            .|..|.|:.:      .|.| ..||:.: ||..:..:.|..::..|.|.|:|.||..|  :...:
Human   128 QQAELQIYFSQGGQAVAIGQFKDRITGS-NDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQ 191

  Fly   168 GYLQVVV------PPIIVEGLTSNDMVVREGQNISLVC-KARGYPEPYVMWRREDGEEMLIGGEH 225
            |.|.|.|      |...|:|....      |..|||.| .|.|.|.|...|.:.:|.:::...|:
Human   192 GILNVSVLVKPSKPLCSVQGRPET------GHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKEN 250

  Fly   226 VNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVIL 290
            .|...| :|.|..::......|.|.|.|.:..| |..:.|....|.:..|...|.|:.:|..:|:
Human   251 FNPTTG-ILVIGNLTNFEQGYYQCTAINRLGNS-SCEIDLTSSHPEVGIIVGALIGSLVGAAIII 313

  Fly   291 E--CHTEAYPASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIR----AVGPNDFG 349
            .  |...                   :.::|..|...:.|::......|:..|    |:...|..
Human   314 SVVCFAR-------------------NKAKAKAKERNSKTIAELEPMTKINPRGESEAMPREDAT 359

  Fly   350 TYRCVAKNSLGET--------DGNIKLDEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALP 406
            .......:|:.||        |...|..:.|.|..|..||                    ..|:|
Human   360 QLEVTLPSSIHETGPDTIQEPDYEPKPTQEPAPEPAPGSE--------------------PMAVP 404

  Fly   407 DYGVE 411
            |..:|
Human   405 DLDIE 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	29/132 (22%)
		IG_like	82..174	CDD:214653	29/132 (22%)
		IG_like	184..267	CDD:214653	23/83 (28%)
		IGc2	191..255	CDD:197706	20/64 (31%)
		IG_like	282..368	CDD:214653	14/99 (14%)
		Ig	288..367	CDD:143165	13/92 (14%)
VSIG1	XP_005262184.1	Ig	97..189	CDD:299845	25/98 (26%)
		IG_like	127..198	CDD:214653	20/71 (28%)
		IG_like	216..289	CDD:214653	22/74 (30%)
		Ig	219..286	CDD:143165	21/68 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910