DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and bdl

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	155/723 - (21%)
Similarity:	246/723 - (34%)	Gaps:	250/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDS--------DFPRFAEPIANV 83
            ||....::|..|:.:||..:.|     |..:..|..|...|:..|        ||| |..||.
  Fly    10 RQSGSALLALLAIILLMNISCT-----SAARDHRRQTNLEAKVGSHVVFNCYIDFP-FDAPIP-- 66

  Fly    84 TVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQ----NSRISLTYNDHRSW---YL 141
                               |.|.|.: |.:.|.:.:....|.    |.|:.|..| |..:   .:
  Fly    67 -------------------YLVHWTK-DNKKIFTWYEQETSTSELFNGRLHLVEN-HPEFGRASV 110

  Fly   142 HIKEVEETDRGWYMCQV---NTDPMRSRKG---YLQVV------VPPIIVEGLTSNDMVVREGQN 194
            ::..:.|:|:|||.|||   |..|.....|   :|.|.      :||:        :..:||||.
  Fly   111 NLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPV--------NQTIREGQT 167

  Fly   195 ISLVCKARGYPEPYVMWRREDGEEMLIGGEHVNVV-------DGEL-LHITKVSRLHMAAYLCVA 251
            ....|..:........|.: ||   ::..|..::|       ||.| :..|.:|.|  ..|.|..
  Fly   168 AFFHCVMKHPENSQASWYK-DG---VLLQEVQDLVRRFYMGPDGSLSIDPTMMSDL--GEYECKV 226

  Fly   252 SNGVPPSISKRVHLRVQF-------PPMLSIPNQLEGAYLGQDVILECHTEAYPASINY-WTTER 308
            .|......:.:..|.:|:       ||.:.:|       .||..:|:||..|.|...|. |  |:
  Fly   227 RNSDGELQTAKAFLNIQYKAKVIYAPPEVFLP-------YGQPAVLDCHFRANPPLKNLRW--EK 282

  Fly   309 GDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPT 373
            ..::....:..|..|:    ::|...:.|     |..|..|:|.|...|.|| |||       |:
  Fly   283 DGLLFDSYNVPGVFYK----MNGSLFFAK-----VDENHAGSYTCTPYNDLG-TDG-------PS 330

  Fly   374 PTTAIISEMSLLNR---SYDGKRRHRNKFDSANALPDYGVEEWRDGAQGNNAGNN------GDNN 429
            |..::|    :|..   |...|..:..|...|..||...::  ||       |||      |..:
  Fly   331 PVISVI----VLRPPIFSVTPKAIYIQKLGEAAELPCEAID--RD-------GNNRPSIIWGRKD 382

  Fly   430 QTPVRNPPGAFHNSAGSLAQHNLLAKIMLGIKTQSFGIFKRLSSSLPLAAGQSFLWLSTLSLVSA 494
            ..|:  |...|..|.|:|.        :.|:.....||::..::             :..:.::|
  Fly   383 GQPL--PADRFSLSGGNLT--------ITGLVEGDRGIYECSAT-------------NEAATITA 424

  Fly   495 PSRWRMSNVENRPNSPETVVNNDTAAECWETRSHCVSESNNNNNSRITQRP-------------- 545
            .:...:.|:  .|.:|..:..|.|     ||   |::         |..:|
  Fly   425 EAELMIENI--APRAPYNLTANST-----ET---CIT---------IRWQPGYLRPNLEYTVWYR 470

  Fly   546 ----PMWARHLRIFH-------IAHTPCGASTQYQRLCE---------RQWQWQRL--------- 581
                |.| |.||:..       :.|...|...::..|.:         :|:::|.|
  Fly   471 LMEAPEW-RTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDF 534

  Fly   582 ----------------------WQWQC---QWKWQHQWQWPM--LICIVILAGCFVRWLPMLLHF 619
                                  |....   |..|...|:.|:  |..:.:.|   |||.....||
  Fly   535 DAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYA---VRWWKEPEHF 596

  Fly   620 IGRHIGTF 627
            :..|..||
  Fly   597 LIGHAETF 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	24/104 (23%)
		IG_like	82..174	CDD:214653	24/110 (22%)
		IG_like	184..267	CDD:214653	20/90 (22%)
		IGc2	191..255	CDD:197706	18/71 (25%)
		IG_like	282..368	CDD:214653	25/86 (29%)
		Ig	288..367	CDD:143165	23/79 (29%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653	26/109 (24%)
		Ig	43..131	CDD:299845	27/111 (24%)
		I-set	153..242	CDD:254352	22/102 (22%)
		Ig	157..242	CDD:299845	21/98 (21%)
		Ig_2	252..337	CDD:290606	31/114 (27%)
		IG_like	260..327	CDD:214653	22/78 (28%)
		I-set	341..428	CDD:254352	22/118 (19%)
		IGc2	356..419	CDD:197706	18/94 (19%)
		FN3	435..524	CDD:238020	18/106 (17%)
		FN3	554..636	CDD:238020	15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810