DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and Sdk1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	566	Identity:	109/566 - (19%)
Similarity:	185/566 - (32%)	Gaps:	163/566 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QQTAQEDSDFPRFAEPIANVTVSVG-RDALMACV-----VENLKGYKVAWVRVDTQTILSIHHNV 122
            :.|...::..|.......|.:|..| .:..:.|:     ||.|   .|.|.|...:....:|
Mouse   265 RDTGTHEAMAPIIVVAPGNRSVVAGSSETTLECIANARPVEEL---SVHWKRNGVRLTSGLH--- 323

  Fly   123 ISQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNT-----DPMRSRKGYLQVVVPPIIVEGL 182
             |...|:::|            .....|.|.|:|:...     :|.|:| .:|.::.||......
Mouse   324 -SYGRRLTIT------------NPTSADTGMYVCEATLRGSTFEPARAR-AFLSIIEPPYFTAEP 374

  Fly   183 TSNDMVVREGQNISLVCKARGYPEPYVMWRREDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAY 247
            .|..:...| :.:.:.|:|.|.|.|.:.|.::......:......|:....|||.|:|......:
Mouse   375 ESRILGEVE-ETMDIPCRAMGVPLPTLQWYKDAVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGIF 438

  Fly   248 LCVASN--------------GVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYP 298
            .|.|||              .:.|:.::|       |...::.:       |...:|.|.....|
Mouse   439 QCFASNEGGEVQTHTYLDVTNIAPAFTQR-------PVDTTVTD-------GMTAVLRCEVSGAP 489

  Fly   299 ASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETD 363
            .....|  :||:.|::..|....::....  ||     .|:|..|...|.|.|.|.|.|    |:
Mouse   490 KPAITW--KRGNHILASGSVRIPRFMLLE--SG-----GLRIAPVFIQDAGNYTCYAAN----TE 541

  Fly   364 GNIKLDEMPT------------------PTTAIISEMSLLNRSYDGKRRHRNKFDSANA------ 404
            .::....|.|                  .|||.:    ....::|.:...|..:...|.
Mouse   542 ASVNASAMLTVWNRTSIVHPPEDRVVIKGTTATL----CCGATHDPRTSLRYVWKKDNVVITASS 602

  Fly   405 ---------------------LPDYGVEEWRDGAQGNNAGNNGDNNQT------PVRNPPGAFHN 442
                                 :.||..|...:|         |.:::|      .:.:||
Mouse   603 SSRIVVEKDGSLVISQTWSGDIGDYTCEIISEG---------GSDSRTARLEVIELPHPP----- 653

  Fly   443 SAGSLAQHNLLAKIMLGIKTQSFGIFKRLSSSLPLAAGQSFL-WLSTLSLVSAPSRWRMSNVENR 506
                   .||||.:.   ..:|..:  .||...|.......| ::..:|..::|.:..:|||  .
Mouse   654 -------QNLLASLS---PARSHSV--TLSWVRPFDGNSPVLYYIVQVSENNSPWKVHLSNV--G 704

  Fly   507 PNSPETVVNNDTAAECWETRSHCVSESNNNNNSRITQR------PP 546
            |......|:..|.|..::.|...|::......|..|.|      ||
Mouse   705 PEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEPP 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/102 (22%)
		IG_like	82..174	CDD:214653	22/102 (22%)
		IG_like	184..267	CDD:214653	20/96 (21%)
		IGc2	191..255	CDD:197706	17/77 (22%)
		IG_like	282..368	CDD:214653	21/85 (25%)
		Ig	288..367	CDD:143165	20/78 (26%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606
		IG_like	100..169	CDD:214653
		IG_like	183..263	CDD:214653
		Ig	197..247	CDD:299845
		IG_like	281..357	CDD:214653	19/94 (20%)
		IGc2	294..347	CDD:197706	15/71 (21%)
		I-set	368..457	CDD:254352	19/89 (21%)
		Ig	388..454	CDD:143165	16/65 (25%)
		I-set	462..552	CDD:254352	25/116 (22%)
		Ig	476..552	CDD:299845	22/88 (25%)
		I-set	557..646	CDD:254352	12/101 (12%)
		Ig	562..646	CDD:299845	12/96 (13%)
		FN3	650..741	CDD:238020	23/109 (21%)
		fn3	753..839	CDD:278470
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810