DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and Kirrel3

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_038937320.1	Gene:	Kirrel3 / 315546	RGDID:	1311382	Length:	869	Species:	Rattus norvegicus

Alignment Length:	330	Identity:	83/330 - (25%)
Similarity:	136/330 - (41%)	Gaps:	60/330 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SKGKHTRLDTQQT---AQEDSDFPRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTI 115
            :|.|..|::..|.   :|:..|         .|.|| |:...:.|.:....|: |.|::  ....
  Rat    35 AKDKFRRMNEGQVYSFSQQPQD---------QVVVS-GQPVTLLCAIPEYDGF-VLWIK--DGLA 86

  Fly   116 LSIHHNVISQNSRISLTYNDHRSWYLHIK--EVEETDRGWYMCQVNTDPMRSRKGYLQVVVP--- 175
            |.:..::.|...  .|...:|.|...|:|  ..|..|...|.||.....:|||...|.|:||
  Rat    87 LGVGRDLSSYPQ--YLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDD 149

  Fly   176 PIIVEGLTSNDMVVREGQNISLVCKA-RGYPEPYVMWRREDGEEMLIGGEHVNVV--DGELLHIT 237
            |||:.|..   :.:|.|..::|.|.| ...|...::|.|:.  |::.|..:...:  ||:...|
  Rat   150 PIILGGPV---ISLRAGDPLNLTCHADNAKPAASIIWLRKG--EVINGATYSKTLLRDGKRESI- 208

  Fly   238 KVSRLHMA--------AYLCVASN-GVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECH 293
             ||.|.::        :.:|.|:| .:|......|.:.:|.||::::..:.:.......|...|.
  Rat   209 -VSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCS 272

  Fly   294 TEAYPASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNS 358
            .:|.||...|...:||. ||.:.|  |:.|.||   ..||.:.:            ...|...|:
  Rat   273 AKANPAVTQYRWAKRGH-IIKEAS--GELYRTT---VDYTYFSE------------PVSCEVTNA 319

  Fly   359 LGETD 363
            ||.|:
  Rat   320 LGSTN 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	24/93 (26%)
		IG_like	82..174	CDD:214653	25/93 (27%)
		IG_like	184..267	CDD:214653	21/94 (22%)
		IGc2	191..255	CDD:197706	18/75 (24%)
		IG_like	282..368	CDD:214653	22/82 (27%)
		Ig	288..367	CDD:143165	22/76 (29%)
Kirrel3	XP_038937320.1	IG_like	54..143	CDD:214653	25/103 (24%)
		Ig strand A'	56..60	CDD:409353	2/12 (17%)
		Ig strand B	64..71	CDD:409353	1/6 (17%)
		Ig strand C	78..82	CDD:409353	2/3 (67%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/5 (0%)
		Ig strand E	104..116	CDD:409353	4/11 (36%)
		Ig strand G	132..143	CDD:409353	4/10 (40%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	25/103 (24%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	0/3 (0%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	22/76 (29%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	1/3 (33%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	2/5 (40%)
		Ig strand G	321..334	CDD:409353	2/4 (50%)
		Ig	335..416	CDD:416386
		Ig strand A'	343..347	CDD:409353
		Ig strand B	350..360	CDD:409353
		Ig strand C	365..371	CDD:409353
		Ig strand E	381..387	CDD:409353
		IgI_5_KIRREL3	418..515	CDD:409479
		Ig strand B	436..440	CDD:409479
		Ig strand C	450..454	CDD:409479
		Ig strand E	481..485	CDD:409479
		Ig strand F	496..501	CDD:409479
		Ig strand G	509..512	CDD:409479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810