DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	170/423 - (40%)
Similarity:	248/423 - (58%)	Gaps:	54/423 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138
            |.|.|.|:||:|:|||||...|.|.:|.||:|.|::.||:.|.:||.|||:.|.|:::::.|..:
  Fly    42 PEFVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNT 106

  Fly   139 WYLHIKEVEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKARG 203
            |.||||.|.|.|||.||||:|||||:|:.|:|.||:||..:...||:|::|.||.::.|.|:|||
  Fly   107 WNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARG 171

  Fly   204 YPEPYVMWRREDGEEMLIGGEHVNV------VDGELLHITKVSRLHMAAYLCVASNGVPPSISKR 262
            ||||.|.||||||.|::: .::|..      ..||:|.::|:||..|.:|||:||||||||:|||
  Fly   172 YPEPIVTWRREDGNEIVL-KDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKR 235

  Fly   263 VHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTS 327
            :.|.:.|.|::.:||||.||.||.||.:|||.||.|.|||||..:.|:||::    :|..:...|
  Fly   236 ISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVT----SGKYHVQES 296

  Fly   328 TVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTPTTAIISEMSLLNRSYDG- 391
            :.|.|...|.:.:|....:|.|:|||:|||||||.|.:|:|.|:|.|.    ...:.||....|
  Fly   297 SQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPN----RNKNPLNGGGKGG 357

  Fly   392 ----------------KRRHRNKFDSANALPDYG-VEEWR-DGAQG------------------- 419
                            |::.:..:...:....|| ||::. :|.:|
  Fly   358 GAGGSLDADANDILKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLTPLSPHVYYTSGNKPA 422

  Fly   420 -NNAGNNGDNNQTPVRNPPGAFHNSAGSLAQHN 451
             :..||:|.|.....::.....||:..:..||:
  Fly   423 THKPGNSGGNQHLHQQHHHHHHHNNNNNNQQHS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	49/91 (54%)
		IG_like	82..174	CDD:214653	49/91 (54%)
		IG_like	184..267	CDD:214653	45/88 (51%)
		IGc2	191..255	CDD:197706	33/69 (48%)
		IG_like	282..368	CDD:214653	39/85 (46%)
		Ig	288..367	CDD:143165	34/78 (44%)
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	41/79 (52%)
		Ig	51..131	CDD:299845	42/79 (53%)
		I-set	144..240	CDD:254352	47/96 (49%)
		IGc2	159..228	CDD:197706	33/69 (48%)
		Ig	244..337	CDD:299845	45/96 (47%)
		I-set	244..337	CDD:254352	45/96 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10955
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
	8	7.950