DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and Ncam2

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	100/489 - (20%)
Similarity:	177/489 - (36%)	Gaps:	131/489 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFRLQAEFNVRQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIA 81
            |...:.|.:.|.:.:.:....|:.|           |.|.                        .
  Rat   189 RVEARGEIDFRDIIVIVNVPPAIVM-----------PQKS------------------------F 218

  Fly    82 NVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRSWYLHIKEV 146
            |.|...|.:..:.|.........::|.|         :..:|.:|.:..|..::..   |.::.:
  Rat   219 NATAERGEEMTLTCKASGSPDPAISWFR---------NGKLIEENEKYILKGSNTE---LTVRNI 271

  Fly   147 EETDRGWYMCQVNTDPMRSRK-GYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKARGYPEPYVM 210
            ...|.|.|:|:........:| .:|||.|.|.|::  ..|:.....| :::|:|:|.|.|.|.:.
  Rat   272 INKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQ--LKNETTSENG-HVTLICEAEGEPVPEIT 333

  Fly   211 WRR-------EDGEE-----MLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRV 263
            |:|       .:|::     :.:.|:|    ....|||..|.......|.|.|::.: ....:.:
  Rat   334 WKRAIDGVTFSEGDKSPDGRIEVKGQH----GRSSLHIRDVKLSDSGRYDCEAASRI-GGHQRSM 393

  Fly   264 HLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTST 328
            ||.:::.|.......:..::.|..:.:.|..:|.|.:..:|..|:..:...:|:     :..|.:
  Rat   394 HLDIEYAPKFVSNQTMYYSWEGNPINISCDVKANPPASIHWRREKLVLPAKNTT-----HLKTHS 453

  Fly   329 VSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLG--------------ETDGNIKLDEMPTPTTAII 379
            |.   :.|.|:|.....||||.|.|.|.|.:|              .:...:|:.|: :.|||.|
  Rat   454 VG---RKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIEL-SQTTAKI 514

  Fly   380 SEMSLLNR--SYDGKRRHRNKFDSANALPDYGVEEWR----DGAQGN------------------ 420
            |    .|:  |:.|...|..:.|    :.:...|.|:    .|.|..
  Rat   515 S----FNKPESHGGVPIHHYQVD----VKEVTSETWKIVRSHGVQTTVVLSSLEPNTTYEVRVAA 571

  Fly   421 -NAGNNGDNN-----QT-PVRNP-PGAFHNSAGS 446
             |....||.:     || |||.| |.:.|....|
  Rat   572 VNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	16/92 (17%)
		IG_like	82..174	CDD:214653	18/92 (20%)
		IG_like	184..267	CDD:214653	22/94 (23%)
		IGc2	191..255	CDD:197706	19/75 (25%)
		IG_like	282..368	CDD:214653	21/99 (21%)
		Ig	288..367	CDD:143165	20/92 (22%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706	100/489 (20%)
		Ig strand B	130..139	CDD:409353
		Ig strand C	145..153	CDD:409353
		Ig strand C'	156..159	CDD:409353
		Ig strand D	162..167	CDD:409353
		Ig strand E	168..175	CDD:409353
		IgI_1_MuSK	209..298	CDD:409562	20/135 (15%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	1/6 (17%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	1/2 (50%)
		Ig	300..397	CDD:416386	25/104 (24%)
		Ig strand A	300..305	CDD:409353	2/4 (50%)
		Ig strand A'	309..313	CDD:409353	1/3 (33%)
		Ig strand B	317..325	CDD:409353	2/7 (29%)
		Ig strand C	331..337	CDD:409353	1/5 (20%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	0/5 (0%)
		Ig strand E	362..368	CDD:409353	2/5 (40%)
		Ig strand F	376..384	CDD:409353	3/7 (43%)
		Ig strand G	387..397	CDD:409353	2/9 (22%)
		Ig_3	401..479	CDD:404760	20/85 (24%)
		Ig strand B	418..422	CDD:409353	0/3 (0%)
		Ig strand C	431..435	CDD:409353	0/3 (0%)
		Ig strand E	458..462	CDD:409353	2/3 (67%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	19/100 (19%)
		fn3	594..678	CDD:394996	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000