DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and Kirrel2

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	313	Identity:	74/313 - (23%)
Similarity:	130/313 - (41%)	Gaps:	36/313 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSI-HHNVISQNSRISLTYNDHR 137
            |.|.:...::.|.:|.:|.:.|.:...:|. |.|    |:..|:: ....:...||..::.|...
Mouse    21 PHFLQQPEDMVVLLGEEARLPCALGAYRGL-VQW----TKDGLALGGERDLPGWSRYWISGNSAS 80

  Fly   138 SWY-LHIKEVEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKA 201
            ..: ||||.||..|...|.||.:...:|||...|.|:|||...:.|....:.:..|...:|.|::
Mouse    81 GQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRS 145

  Fly   202 RG--YPEPYVMWRRE----DG---EEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVA-SNGVP 256
            ||  .|.|.::|.|:    ||   .:..:..:....|:..|. :|..|....|..:|.| |..:|
Mouse   146 RGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLF-LTPSSHDDGATLICRARSQALP 209

  Fly   257 PSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGD 321
            ......|.|.:|:|||:::..:.:....|:.|...|...|.|....|...:.|..::   ...|.
Mouse   210 TGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVL---GARGP 271

  Fly   322 KYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKLDEMPTP 374
            :.|..:..:..|:.:.               |...|::|..:.:..|:.:..|
Mouse   272 RLEVVADATFLTEPVS---------------CEVSNAVGSANRSTALEVLYGP 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	26/93 (28%)
		IG_like	82..174	CDD:214653	27/93 (29%)
		IG_like	184..267	CDD:214653	22/92 (24%)
		IGc2	191..255	CDD:197706	19/73 (26%)
		IG_like	282..368	CDD:214653	13/85 (15%)
		Ig	288..367	CDD:143165	12/78 (15%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	26/93 (28%)
		Ig	122..220	CDD:416386	23/98 (23%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	2/6 (33%)
		Cell attachment site. /evidence=ECO:0000255	146..148		1/1 (100%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	2/8 (25%)
		Ig strand F	197..205	CDD:409353	3/7 (43%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	14/86 (16%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	2/23 (9%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386
		Ig strand A'	316..321	CDD:409353
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900