DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and IGSF9B

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	363	Identity:	95/363 - (26%)
Similarity:	144/363 - (39%)	Gaps:	83/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDFPRFAEPIANVTVSVGRDALMAC 95
            |..:||...:::.|     ..:.::|.|       ..:|:.:|         ||...|...::.|
Human     2 IWYVATFIASVIGT-----RGLAAEGAH-------GLREEPEF---------VTARAGESVVLRC 45

  Fly    96 -VVENLKG----YKVAWVRVDTQTILSIH------HNVISQNSRISLTYNDHRSWYLHIKEVEET 149
             |:..:.|    |.|.|.:......:.|.      |.......|.||    |....|.:::|...
Human    46 DVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASL----HDKASLRLEQVRSE 106

  Fly   150 DRGWYMCQV-----NTDPMRSRKG-YLQVVVPPIIVEGLTSNDMV-VREGQNISLVCKARGYPEP 207
            |:|||.|:|     ..|...:... :|.:..||...|  |....: .:||.:|::.|.|.|.|:|
Human   107 DQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTE--TPPQYIEAKEGGSITMTCTAFGNPKP 169

  Fly   208 YVMWRREDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPM 272
            .|.|.:| |..:...|:: .|.||.|. :|.|||....||.|.|.: :........||.||.||.
Human   170 IVTWLKE-GTLLGASGKY-QVSDGSLT-VTSVSREDRGAYTCRAYS-IQGEAVHTTHLLVQGPPF 230

  Fly   273 LSIPNQLEGAYLGQDVILECHTEAYPASIN---YWTTERGDMIISDTSRAGDKYETTSTVSGYTK 334
            :..|.:.....:.||.:|.|..||||.::.   ||..|             :.|        :..
Human   231 IVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDE-------------NVY--------FQN 274

  Fly   335 YMKLKIR----------AVGPNDFGTYRCVAKNSLGET 362
            .:||::|          .|.|.|.|.|.||..||||.:
Human   275 DLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRS 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	25/108 (23%)
		IG_like	82..174	CDD:214653	25/108 (23%)
		IG_like	184..267	CDD:214653	27/83 (33%)
		IGc2	191..255	CDD:197706	25/63 (40%)
		IG_like	282..368	CDD:214653	26/94 (28%)
		Ig	288..367	CDD:143165	24/88 (27%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	23/97 (24%)
		Ig	41..115	CDD:143165	19/77 (25%)
		I-set	139..225	CDD:254352	30/91 (33%)
		IGc2	153..210	CDD:197706	24/59 (41%)
		I-set	229..321	CDD:254352	28/105 (27%)
		Ig	235..321	CDD:299845	26/99 (26%)
		IG_like	331..414	CDD:214653
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910