DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and Iglon5

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001157990.1	Gene:	Iglon5 / 210094	MGIID:	2686277	Length:	336	Species:	Mus musculus

Alignment Length:	392	Identity:	112/392 - (28%)
Similarity:	165/392 - (42%)	Gaps:	75/392 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPRPHTRRRFRLQAEFNVRQLAITIIATAAVTMLMTATPTLAEIPSKGKHTRLDTQQTAQEDSDF 73
            :|.|....|.||        ||...:|..||.             |:|    |.:|..
Mouse     1 MPPPAPGARLRL--------LAAAALAGLAVI-------------SRG----LLSQSL------- 33

  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138
             .|:.|..|.||..|.:|.::|.::. ...:|||  ::...||...::..:.:.|:.|..|....
Mouse    34 -EFSSPADNYTVCEGDNATLSCFIDE-HVTRVAW--LNRSNILYAGNDRWTSDPRVRLLINTPEE 94

  Fly   139 WYLHIKEVEETDRGWYMCQVNT--DPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKA 201
            :.:.|.:|...|.|.|.|...|  .|..::. ||.|.||..||.  .|:.:.|.||.|::|:|.|
Mouse    95 FSILITQVGLGDEGLYTCSFQTRHQPYTTQV-YLIVHVPARIVN--ISSPVAVNEGGNVNLLCLA 156

  Fly   202 RGYPEPYVMWRR-EDGEEMLIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGV--PPSISKRV 263
            .|.|||.|.||: .||          ...:||:|.|:.:.|.....|.||..|||  .|. |:||
Mouse   157 VGRPEPTVTWRQLRDG----------FTSEGEILEISDIQRGQAGEYECVTHNGVNSAPD-SRRV 210

  Fly   264 HLRVQFPPMLSIPNQLEGAYLGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTST 328
            .:.|.:||.::.......| ||:..:|.|...|.|.:...|  .:.|.::|..|..|.|.:|..|
Mouse   211 LVTVNYPPTITDVTSARTA-LGRAALLRCEAMAVPPADFQW--YKDDRLLSSGSAEGLKVQTERT 272

  Fly   329 VSGYTKYMKLKIRAVGPNDFGTYRCVAKNSLGETDGNIKL----------DEMPTPTTAIISEMS 383
            .|      .|....|....:|.|.|.|.|.||.:..:::|          ...|.|.| ::|.:|
Mouse   273 RS------MLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGPLT-LLSALS 330

  Fly   384 LL 385
            .|
Mouse   331 WL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	24/93 (26%)
		IG_like	82..174	CDD:214653	25/93 (27%)
		IG_like	184..267	CDD:214653	32/85 (38%)
		IGc2	191..255	CDD:197706	24/64 (38%)
		IG_like	282..368	CDD:214653	25/85 (29%)
		Ig	288..367	CDD:143165	22/78 (28%)
Iglon5	NP_001157990.1	Ig	41..129	CDD:416386	24/91 (26%)
		Ig strand A'	41..46	CDD:409353	3/4 (75%)
		Ig strand B	48..56	CDD:409353	2/7 (29%)
		CDR1	56..60	CDD:409353	0/4 (0%)
		FR2	61..68	CDD:409353	3/8 (38%)
		Ig strand C	61..67	CDD:409353	3/7 (43%)
		CDR2	69..79	CDD:409353	2/9 (22%)
		Ig strand C'	71..74	CDD:409353	2/2 (100%)
		Ig strand C'	76..79	CDD:409353	0/2 (0%)
		FR3	80..115	CDD:409353	9/34 (26%)
		Ig strand D	84..91	CDD:409353	2/6 (33%)
		Ig strand E	94..100	CDD:409353	0/5 (0%)
		Ig strand F	107..115	CDD:409353	3/7 (43%)
		CDR3	116..120	CDD:409353	1/3 (33%)
		Ig strand G	120..129	CDD:409353	3/9 (33%)
		FR4	122..129	CDD:409353	2/7 (29%)
		Ig strand A	132..137	CDD:409353	2/4 (50%)
		Ig_3	134..199	CDD:404760	27/76 (36%)
		Ig strand A'	140..145	CDD:409353	0/4 (0%)
		Ig strand B	148..157	CDD:409353	3/8 (38%)
		Ig strand C	163..167	CDD:409353	1/3 (33%)
		Ig strand D	174..177	CDD:409353	0/2 (0%)
		Ig strand E	178..183	CDD:409353	2/4 (50%)
		Ig strand F	191..199	CDD:409353	3/7 (43%)
		Ig_3	217..295	CDD:404760	24/86 (28%)
		putative Ig strand A	218..224	CDD:409353	1/5 (20%)
		Ig strand B	234..238	CDD:409353	1/3 (33%)
		Ig strand C	247..251	CDD:409353	1/5 (20%)
		Ig strand E	274..278	CDD:409353	2/9 (22%)
		Ig strand F	288..293	CDD:409353	2/4 (50%)
		Ig strand G	301..304	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833621
Domainoid	1	1.000	45	1.000	Domainoid score	I12107
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8732
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.750