DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-kappa and DSCAM

DIOPT Version :9

Sequence 1:NP_723828.1 Gene:DIP-kappa / 318958 FlyBaseID:FBgn0051814 Length:672 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:648 Identity:134/648 - (20%)
Similarity:204/648 - (31%) Gaps:232/648 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVISQNSRISLTYNDHRS 138
            |....|:.|:|...|||..:.|.|.....|.:.|.:  ...:|..:|..::..:..:|..:|.: 
Human   504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NSNLLPFNHRQVAFENNGTLKLSDVQ- 565

  Fly   139 WYLHIKEVEETDRGWYMCQVNTDPM--RSRKGYLQVVVPP--------------------IIVEG 181
                    :|.|.|.|.|.|...|.  .|:..::.|.|||                    ::|.|
Human   566 --------KEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 622

  Fly   182 ---------------------------LTS-----------------------------NDMVVR 190
                                       .||                             :.::||
Human   623 DLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687

  Fly   191 ---------------EGQNISLVCKARGYPEPYVMWRREDG------EEMLIGGEHVNVVDGELL 234
                           .|:.:.|.|.|.|||.|.::|:...|      :.:.:.|....:.:|.||
Human   688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL 752

  Fly   235 HITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPML-SIPNQLEGAYLGQDVILECHTEAYP 298
             |..|.......|||..||.|...:||.::|.|:.|.|: |.||... |..||...:.|......
Human   753 -IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL-ATQGQKKEMSCTAHGEK 815

  Fly   299 ASINYWTTERGDMIIS--------DTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYRCVA 355
            ..|..|  |:.|.||:        .|...|:  |..||         |:|......|.|.:.|.|
Human   816 PIIVRW--EKEDRIINPEMARYLVSTKEVGE--EVIST---------LQILPTVREDSGFFSCHA 867

  Fly   356 KNSLGETDGNIKL--DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVE------E 412
            .||.||..|.|:|  .|.|.|....|.::.....:.    |....||..:.:..|.:|      .
Human   868 INSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITL----RWTMGFDGNSPITGYDIECKNKSDS 928

  Fly   413 WRDGAQ-----------------------------GNNAGNNGDNNQTPVR-------NPPGAFH 441
            | |.||                             .|..|.:..:|:..:.       .||...|
Human   929 W-DSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVH 992

  Fly   442 ---NSAGSL----------AQHNLLAKIMLGIKTQSFG-----------------------IFKR 470
               .|:.|:          .|:.::....:|.:..|.|                       :.|.
Human   993 LEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF 1057

  Fly   471 LSSSLPLAA------GQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVVNNDTAAECWETRS 527
            ....|.:.|      |.|...:.|.:|...|| :...||:....|||::      :..|.|.|
Human  1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPS-YPPENVQAIATSPESI------SISWSTLS 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-kappaNP_723828.1 Ig 80..172 CDD:299845 21/93 (23%)
IG_like 82..174 CDD:214653 22/93 (24%)
IG_like 184..267 CDD:214653 28/132 (21%)
IGc2 191..255 CDD:197706 21/69 (30%)
IG_like 282..368 CDD:214653 27/93 (29%)
Ig 288..367 CDD:143165 23/86 (27%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449
IGc2 518..575 CDD:197706 15/67 (22%)
I-set 596..686 CDD:333254 6/89 (7%)
Ig_DSCAM 707..784 CDD:143211 24/77 (31%)
Ig 802..889 CDD:325142 29/99 (29%)
FN3 885..978 CDD:238020 15/97 (15%)
FN3 986..1083 CDD:238020 15/96 (16%)
FN3 1091..1184 CDD:238020 8/29 (28%)
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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