DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and Dscam

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	146/728 - (20%)
Similarity:	224/728 - (30%)	Gaps:	269/728 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ITIIATAAVTMLMTATPTLAEIP-SKGKHTRLDTQQTAQ--------------EDSDF------- 73
            ::::.....|.|.|.|.||.:.| .||...|:....|::              .|...
  Rat   424 VSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANN 488

  Fly    74 ---------------PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVI 123
                           |....|:.|:|...|||..:.|.|.....|.:.|.:  ...:|..:|..:
  Rat   489 SAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NANLLPFNHRQV 551

  Fly   124 SQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTDPM--RSRKGYLQVVVPP---------- 176
            :..:..:|..:|.:         :|.|.|.|.|.|...|.  .|:..::.|.|||
  Rat   552 AFENNGTLKLSDVQ---------KEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRF 607

  Fly   177 ----------IIVEG---------------------------LTS-------------------- 184
                      ::|.|                           .||
  Rat   608 SIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672

  Fly   185 ---------NDMVVR---------------EGQNISLVCKARGYPEPYVMWRREDG------EEM 219
                     :.::||               .|:.:.|.|.|.|||.|.::|:...|      :.:
  Rat   673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPI 737

  Fly   220 LIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPML-SIPNQLEGAY 283
            .:.|....:.:|.|| |..|.......|||..||.|...:||.::|.|:.|.|: |.||... |.
  Rat   738 ALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL-AT 800

  Fly   284 LGQDVILECHTEAYPASINYWTTERGDMIIS--------DTSRAGDKYETTSTVSGYTKYMKLKI 340
            .||...:.|........|..|  |:.|.||:        .|...|:  |..||         |:|
  Rat   801 QGQRKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEVGE--EVIST---------LQI 852

  Fly   341 RAVGPNDFGTYRCVAKNSLGETDGNIKL--DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSAN 403
            ......|.|.:.|.|.||.||..|.|:|  .|.|.|....|.::.....:.    |....||..:
  Rat   853 LPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITL----RWTMGFDGNS 913

  Fly   404 ALPDYGVE------EWRDGAQ-----------------------------GNNAGNNGDNNQTPV 433
            .:..|.:|      .| |.||                             .|..|.:..:|:..:
  Rat   914 PITGYDIECKNKSDSW-DSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEITI 977

  Fly   434 R-------NPPGAFH---NSAGSL----------AQHNLLAKIMLGIKTQSFG------------ 466
            .       .||...|   .|:.|:          .|:.::....:|.:..|.|
  Rat   978 TADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISIDT 1042

  Fly   467 -----------IFKRLSSSLPLAA------GQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVV 514
                       :.|.....|.:.|      |.|...:.|.:|...|| :...||:....|||::
  Rat  1043 TGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS-YPPENVQAIATSPESI- 1105

  Fly   515 NNDTAAECWETRS 527
                 :..|.|.|
  Rat  1106 -----SISWSTLS 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	21/93 (23%)
		IG_like	82..174	CDD:214653	22/93 (24%)
		IG_like	184..267	CDD:214653	28/132 (21%)
		IGc2	191..255	CDD:197706	21/69 (30%)
		IG_like	282..368	CDD:214653	27/93 (29%)
		Ig	288..367	CDD:143165	23/86 (27%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386	12/76 (16%)
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353	0/6 (0%)
		Ig strand C	436..442	CDD:409353	2/5 (40%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	1/7 (14%)
		Ig strand E	464..473	CDD:409353	0/8 (0%)
		Ig strand F	480..488	CDD:409353	0/7 (0%)
		Ig strand G	491..501	CDD:409353	0/9 (0%)
		Ig	504..593	CDD:416386	23/99 (23%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	2/3 (67%)
		Ig strand B	519..526	CDD:409353	2/6 (33%)
		Ig strand C	533..539	CDD:409353	2/5 (40%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	1/5 (20%)
		Ig strand F	571..579	CDD:409353	4/7 (57%)
		Ig strand G	583..593	CDD:409353	1/9 (11%)
		Ig	596..686	CDD:416386	6/89 (7%)
		Ig strand A	597..599	CDD:409353	1/1 (100%)
		Ig strand B	611..620	CDD:409353	0/8 (0%)
		Ig strand C	625..632	CDD:409353	0/6 (0%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	0/4 (0%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
		Ig strand F	665..673	CDD:409353	0/7 (0%)
		Ig strand G	676..685	CDD:409353	0/8 (0%)
		Ig_DSCAM	689..784	CDD:409397	25/95 (26%)
		Ig strand B	707..711	CDD:409397	1/3 (33%)
		Ig strand C	720..724	CDD:409397	0/3 (0%)
		Ig strand E	749..753	CDD:409397	3/4 (75%)
		Ig strand F	763..768	CDD:409397	3/4 (75%)
		Ig strand G	777..780	CDD:409397	2/2 (100%)
Ig_DSCAM	785..884	CDD:409398	33/112 (29%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	2/5 (40%)
Ig strand E	848..852	CDD:409398	3/12 (25%)
Ig strand F	862..867	CDD:409398	1/4 (25%)
Ig strand G	875..878	CDD:409398	1/2 (50%)
FN3	885..978	CDD:238020	15/97 (15%)
FN3	986..1083	CDD:238020	15/96 (16%)
FN3	1091..1184	CDD:238020	8/29 (28%)
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810