DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and IGSF5

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_011527774.1	Gene:	IGSF5 / 150084	HGNCID:	5952	Length:	497	Species:	Homo sapiens

Alignment Length:	475	Identity:	93/475 - (19%)
Similarity:	145/475 - (30%)	Gaps:	197/475 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 NVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIH-HNVISQNSRISLTYNDHRSWYLHIKE 145
            ::|.:..||.:..|.|                 :.|:| |..:.| :|.:      |.::||
Human    62 SLTSNFSRDGVCFCSV-----------------VKSLHAHRGLLQ-ARAA------RFYFLH--- 99

  Fly   146 VEETDRGWYMCQVNTDPMRSRKGYLQVVVPPIIVE---GLTSNDMVVREGQNISLV--------C 199
                          .|...:..|....::..|.:|   |..|.:.|:...||..::        |
Human   100 --------------QDSSHATNGESSQLLELIFLEKNAGSGSGNEVIEGPQNARVLKGSQARFNC 150

  Fly   200 K-ARGYPEPYVMW-------------------------RREDG----EEMLIGGEHVNVVD-GEL 233
            . ::|:  ..:||                         |.:.|    .||:|  .:|...| |.:
Human   151 TVSQGW--KLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMII--HNVEPSDSGNI 211

  Fly   234 LHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPMLSIPNQLEGAYLGQDVILE---CHTE 295
            ....:.||||.:|||.|...|            ..|.|.:::            |:.|   |...
Human   212 RCSLQNSRLHGSAYLTVQVMG------------ELFIPSVNL------------VVAENEPCEVT 252

  Fly   296 AYPASINYWTT------ERGDMIISDTSR--AGDKYETTSTVSGYTKYMKLKIRAVGPNDFGTYR 352
            ..|   ::||.      |.| :::|.:|.  ..:..:..|.||         |.|:.|...||..
Human   253 CLP---SHWTRLPDISWELG-LLVSHSSYYFVPEPSDLQSAVS---------ILALTPQSNGTLT 304

  Fly   353 CVAK-NSL----------------GETDGNIK----LDEMP----------------------TP 374
            |||. .||                .:|.|.|.    |..:|                      ||
Human   305 CVATWKSLKARKSATVNLTVIRCPQDTGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTP 369

  Fly   375 TTAIISEMSLLNRSYDG-------------KRRHRNKFDSANALPDYGVEEWRDGAQGN-NAGNN 425
            |..:........|...|             ||..|.:|...:.......|  .:...|| |:|.|
Human   370 TCTLTIRCCCCRRRCCGCNCCCRCCFCCRRKRGFRIQFQKKSEKEKTNKE--TETESGNENSGYN 432

  Fly   426 GDNNQT--PVRNPPGAFHNS 443
            .|..:|  ....||.:..:|
Human   433 SDEQKTTDTASLPPKSCESS 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	15/90 (17%)
		IG_like	82..174	CDD:214653	15/92 (16%)
		IG_like	184..267	CDD:214653	25/121 (21%)
		IGc2	191..255	CDD:197706	22/102 (22%)
		IG_like	282..368	CDD:214653	26/117 (22%)
		Ig	288..367	CDD:143165	25/106 (24%)
IGSF5	XP_011527774.1	IG_like	135..228	CDD:214653	21/96 (22%)
		Ig	<200..230	CDD:299845	12/31 (39%)
		Ig	236..307	CDD:299845	20/95 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840