DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and BTNL3

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_932079.1	Gene:	BTNL3 / 10917	HGNCID:	1143	Length:	466	Species:	Homo sapiens

Alignment Length:	353	Identity:	62/353 - (17%)
Similarity:	115/353 - (32%)	Gaps:	139/353 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 PNQLEGAYLGQDVILEC----HTEAYPASINYWTTERGDMIISDTSRAGDKYETTS--TVSGYTK 334
            |.:...|.:|:|.:..|    .|.|....:.::..:...::  ...|.|:.:|:..  ...|.|:
Human    24 PGKFVQALVGEDAVFSCSLFPETSAEAMEVRFFRNQFHAVV--HLYRDGEDWESKQMPQYRGRTE 86

  Fly   335 YMK---------LKIRAVGPNDFGTYRC-----------------VAKNSL------GETDGNIK 367
            ::|         |:::.:.|:|.|.|.|                 .|..||      |..||.|:
Human    87 FVKDSIAGGRVSLRLKNITPSDIGLYGCWFSSQIYDEEATWELRVAALGSLPLISIVGYVDGGIQ 151

  Fly   368 L-----DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVEEWRDGAQGNNAGNNGD 427
            |     ...|.||.                                   :|: |.||.:..::..
Human   152 LLCLSSGWFPQPTA-----------------------------------KWK-GPQGQDLSSDSR 180

  Fly   428 NNQTPVRNPPG----------AFHNSAGSL--------AQHNLLAKIMLGIKTQSFGIFK----R 470
                  .|..|          ....:|||:        ..|.:.:|:::|   ::|  |:    |
Human   181 ------ANADGYSLYDVEISIIVQENAGSILCSIHLAEQSHEVESKVLIG---ETF--FQPSPWR 234

  Fly   471 LSSSL---------PLAAGQSFLWLSTLSLVSAPSRWRMSN-----VENRPNSPETVVNNDTAAE 521
            |:|.|         .:..|...::..:...:.|...||..:     .:.|.::.|..::.:||
Human   235 LASILLGLLCGALCGVVMGMIIVFFKSKGKIQAELDWRRKHGQAELRDARKHAVEVTLDPETA-- 297

  Fly   522 CWETRSH---CVSESNNNNNSRITQRPP 546
                  |   |||:.....:.:..|..|
Human   298 ------HPKLCVSDLKTVTHRKAPQEVP 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845
		IG_like	82..174	CDD:214653
		IG_like	184..267	CDD:214653
		IGc2	191..255	CDD:197706
		IG_like	282..368	CDD:214653	25/123 (20%)
		Ig	288..367	CDD:143165	21/116 (18%)
BTNL3	NP_932079.1	Ig_MOG_like	33..132	CDD:319291	17/100 (17%)
BTNL3	NP_932079.1	SPRY_PRY_C-I_1	289..461	CDD:293968	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910