DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-kappa and CHL1

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_006605.2	Gene:	CHL1 / 10752	HGNCID:	1939	Length:	1224	Species:	Homo sapiens

Alignment Length:	635	Identity:	119/635 - (18%)
Similarity:	200/635 - (31%)	Gaps:	223/635 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EDSDF-----PRF-AEPIANVTVSVGRDALMAC-VVENLKGYKVAWVRVDTQTILSIHHNVISQN 126
            |:.:|     |:| .|.|..:.|..|...::.| ..:.|....:.|:.::      :.|  |.|:
Human   121 EEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIE------LEH--IEQD 177

  Fly   127 SRISLTYNDHRSWYLHIKEVEETD-RGWYMC------------------QVNT------------ 160
            .|:.::....    |:...|||.| |..|.|                  .||:
Human   178 ERVYMSQKGD----LYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTE 238

  Fly   161 -----DPMRSRKGYLQVVVPPIIVEGLTSNDMVVREGQNISLVCKARGYPEPYVMWRREDGEEML 220
                 :.::.||.  ::::||  .|..:.:.:.:.:|:.:.|.|.|.|.|.|.|.|.:..|:  |
Human   239 IGSKANSIKQRKP--KLLLPP--TESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGD--L 297

  Fly   221 IGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPMLSIPNQLEGAYLG 285
            ..|.......|:.|.|..||......|.|.|||.: .:.:...|:.|:.||..:...|......|
Human   298 PKGRETKENYGKTLKIENVSYQDKGNYRCTASNFL-GTATHDFHVIVEEPPRWTKKPQSAVYSTG 361

  Fly   286 QDVILECHTEAYPASINYWTTE---------RGDMI----ISDT--------------------- 316
            .:.||.|..|..|.....|...         .||::    ||.|
Human   362 SNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTI 426

  Fly   317 ----------------SRAGDKYETTSTVSGYTKYMKL-------------KIRAVGP------- 345
                            ::.|:.|   :||.||:.::..             |:..|.|
Human   427 LANANIDVVDVRPLIQTKDGENY---ATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYH 488

  Fly   346 --------------NDFGTYRCVAKNSLGETDGNIKLD------EMPTPTTAIISEMSLL----N 386
                          .|.|:|.|..:|::|:|.....||      ...:|....|.::.:|    .
Human   489 IYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCE 553

  Fly   387 RSYDGKRRHRNKFD---SANALPDYGVEEWR---DGAQGNNAGNNGDNNQTPVRNPPGAFHNSAG 445
            ...|...:|..|..   ...|....|.|:.|   |||
Human   554 SKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGA---------------------------- 590

  Fly   446 SLAQHNLLAKIMLGIKTQSFGIFKRLSSSLPLAAGQSFLWLSTLSLVSAPSRWRMSNVENRPNSP 510
                 ||   .:..:..:..||: ..|:...|.:......::.|.:...|....:|..:||
Human   591 -----NL---TISNVTLEDQGIY-CCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNR---- 642

  Fly   511 ETVVNNDTAAECWETRSHCVSESNNNNNSRIT------QRPPMWARHLRI 554
                   :....||..    ::.|:|.:..|.      :.|..|....|:
Human   643 -------SVRLTWEAG----ADHNSNISEYIVEFEGNKEEPGRWEELTRV 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	22/128 (17%)
		IG_like	82..174	CDD:214653	21/128 (16%)
		IG_like	184..267	CDD:214653	23/82 (28%)
		IGc2	191..255	CDD:197706	22/63 (35%)
		IG_like	282..368	CDD:214653	28/169 (17%)
		Ig	288..367	CDD:143165	27/162 (17%)
CHL1	NP_006605.2	Ig	55..126	CDD:299845	1/4 (25%)
		Ig2_L1-CAM_like	129..223	CDD:143253	21/105 (20%)
		IG_like	140..224	CDD:214653	17/95 (18%)
		IG_like	264..343	CDD:214653	23/81 (28%)
		Ig3_L1-CAM_like	274..344	CDD:143208	22/72 (31%)
		IG_like	353..434	CDD:214653	13/80 (16%)
		Ig4_L1-NrCAM_like	361..435	CDD:143179	12/73 (16%)
		IG_like	447..525	CDD:214653	15/80 (19%)
		Ig	457..525	CDD:299845	10/67 (15%)
		IG_like	548..624	CDD:214653	17/112 (15%)
		Ig	548..616	CDD:143165	17/104 (16%)
		DGEA	571..574		0/2 (0%)
		FN3	628..717	CDD:238020	12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..732
		fn3	731..811	CDD:278470
		FN3	834..927	CDD:238020
		FN3	932..1027	CDD:238020
		Bravo_FIGEY	1120..1205	CDD:290593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1179
		FIG[AQ]Y	1197..1201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100