DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-kappa and dscam

DIOPT Version :9

Sequence 1:	NP_723828.1	Gene:	DIP-kappa / 318958	FlyBaseID:	FBgn0051814	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	722	Identity:	144/722 - (19%)
Similarity:	220/722 - (30%)	Gaps:	256/722 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ITIIATAAVTMLMTATPTLAEIP--SKGKH--TRLDTQQ----------------------TAQE 69
            ::::.....|.|.|.|.||.:.|  ..|.|  ::|.|.:                      ||..
Frog   424 VSLMCNVKGTPLPTITWTLDDDPIIKNGNHRISQLITSEGNVVSYLNITNTQVRDGGVYRCTANN 488

  Fly    70 DSDF-----------PRFAEPIANVTVSVGRDALMACVVENLKGYKVAWVRVDTQTILSIHHNVI 123
            .:..           |....|:.|:|...|||..:.|.|.....|.:.|.:  ...:|..:|..:
Frog   489 SAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NSNLLPFNHRQV 551

  Fly   124 SQNSRISLTYNDHRSWYLHIKEVEETDRGWYMCQVNTDPM--RSRKGYLQVVVPP---------- 176
            :..:..:|..:|.:         ::.|.|.|||.|...|.  .|:..::.|.|||
Frog   552 AFENNGTLKLSDVQ---------KDVDEGEYMCNVLVQPQLSTSQSVHVTVKVPPFIQPFESQRF 607

  Fly   177 ----------IIVEG-----------------------------------------------LTS 184
                      ::|.|                                               :..
Frog   608 SIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672

  Fly   185 ND---------MVVR---------------EGQNISLVCKARGYPEPYVMWRREDG------EEM 219
            ||         ::||               .|:.:.|.|.|.|||.|.::|:...|      :.:
Frog   673 NDAAAVEHQSQLIVRVPPRFVVQPTDQDGIYGKAVILNCSAEGYPVPTIVWKYSKGAGVPQFQPI 737

  Fly   220 LIGGEHVNVVDGELLHITKVSRLHMAAYLCVASNGVPPSISKRVHLRVQFPPML-SIPNQLEGAY 283
            .:.|....:.:|.|| |..|.......|||..||.|...:||.::|.|:.|.|: |.||... |.
Frog   738 ALNGRIQLLTNGSLL-IKHVLEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL-AT 800

  Fly   284 LGQDVILECHTEAYPASINYWTTERGDMIISDTSRAGDKYETTSTVSGYTKYMKLKIRAVGPNDF 348
            .||...:.|........|..|..|...:.:.:.||    |..::...|......|:|......|.
Frog   801 QGQKKEMSCTAHGEKPIIVRWEKEDRMINVPEMSR----YLVSTKEVGEEVISTLQILPTVREDS 861

  Fly   349 GTYRCVAKNSLGETDGNIKL--DEMPTPTTAIISEMSLLNRSYDGKRRHRNKFDSANALPDYGVE 411
            |.:.|.|.||.||..|.|:|  .|.|.|....|.|:    |:.....|....||..:.:..|.:|
Frog   862 GFFSCHAINSFGEDRGIIQLTVQEPPDPPEIEIREV----RARSIALRWTMGFDGNSPITGYDIE 922

  Fly   412 ------EWRDGAQ-----------------------------GNNAGNNGDNNQTPVR------- 434
                  .| |..|                             .|..|.:..:|:..:.
Frog   923 CKNKSDSW-DSVQRTKDVSPQLNQATIIDLHPASTYNIRMYAKNRIGKSEASNELTITTEEAAPD 986

  Fly   435 NPP----------------------------------GAFHNSAGSLAQHNLLAKIMLG------ 459
            .||                                  |....|.|...|.|::.....|
Frog   987 GPPQEVQLDPISSQSIRVTWKAPKKHLQNGIIRGYKIGFREYSTGGNYQFNIIDVDTTGDSEVYT 1051

  Fly   460 ----IKTQSFGIFKRLSSSLPLAAGQSFLWLSTLSLVSAPSRWRMSNVENRPNSPETVVNNDTAA 520
                .|...:|:..:..:.  ...|.|...:.|.:|...||| ...||:....||||:..:
Frog  1052 LDNLKKFTQYGVVVQACNR--AGTGPSSQEIITTTLEDVPSR-SPENVQASSTSPETITIS---- 1109

  Fly   521 ECWETRS 527
              |.|.|
Frog  1110 --WSTPS 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-kappa	NP_723828.1	Ig	80..172	CDD:299845	21/93 (23%)
		IG_like	82..174	CDD:214653	22/93 (24%)
		IG_like	184..267	CDD:214653	29/112 (26%)
		IGc2	191..255	CDD:197706	21/69 (30%)
		IG_like	282..368	CDD:214653	23/85 (27%)
		Ig	288..367	CDD:143165	19/78 (24%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386
		Ig strand A'	127..136	CDD:409353
		Ig strand B	140..147	CDD:409353
		Ig strand C	157..162	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand D	172..176	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	205..217	CDD:409353
		Ig strand A	225..228	CDD:409353
		Ig strand A'	234..237	CDD:409353
		IG_like	236..310	CDD:214653
		Ig strand B	242..249	CDD:409353
		Ig strand C	255..260	CDD:409353
		Ig strand C'	262..264	CDD:409353
		Ig strand D	270..274	CDD:409353
		Ig strand E	276..280	CDD:409353
		Ig strand F	289..297	CDD:409353
		Ig strand G	300..310	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386	13/76 (17%)
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353	0/6 (0%)
		Ig strand C	436..442	CDD:409353	2/5 (40%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	2/7 (29%)
		Ig strand E	464..473	CDD:409353	0/8 (0%)
		Ig strand F	480..488	CDD:409353	2/7 (29%)
		Ig strand G	491..501	CDD:409353	0/9 (0%)
		Ig	504..593	CDD:416386	23/99 (23%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	2/3 (67%)
		Ig strand B	519..526	CDD:409353	2/6 (33%)
		Ig strand C	533..539	CDD:409353	2/5 (40%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	1/5 (20%)
		Ig strand F	571..579	CDD:409353	5/7 (71%)
		Ig strand G	583..593	CDD:409353	1/9 (11%)
		Ig	596..686	CDD:416386	6/89 (7%)
		Ig strand A	597..599	CDD:409353	1/1 (100%)
		Ig strand A'	604..608	CDD:409353	0/3 (0%)
		Ig strand B	611..620	CDD:409353	0/8 (0%)
		Ig strand C	625..632	CDD:409353	0/6 (0%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	0/4 (0%)
		Ig strand E	651..658	CDD:409353	0/6 (0%)
Ig strand F	665..673	CDD:409353	0/7 (0%)
Ig strand G	676..685	CDD:409353	0/8 (0%)
Ig_DSCAM	689..784	CDD:409397	25/95 (26%)
Ig strand B	707..711	CDD:409397	1/3 (33%)
Ig strand C	720..724	CDD:409397	0/3 (0%)
Ig strand E	749..753	CDD:409397	3/4 (75%)
Ig strand F	763..768	CDD:409397	3/4 (75%)
Ig strand G	777..780	CDD:409397	2/2 (100%)
Ig_DSCAM	785..885	CDD:409398	29/104 (28%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	1/3 (33%)
Ig strand E	849..853	CDD:409398	1/3 (33%)
Ig strand F	863..868	CDD:409398	1/4 (25%)
Ig strand G	876..879	CDD:409398	1/2 (50%)
FN3	886..980	CDD:238020	16/98 (16%)
FN3	987..1084	CDD:238020	13/98 (13%)
FN3	1093..1185	CDD:238020	9/28 (32%)
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910