DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31810 and HSDL1

DIOPT Version :9

Sequence 1:	NP_724023.1	Gene:	CG31810 / 318955	FlyBaseID:	FBgn0051810	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_113651.4	Gene:	HSDL1 / 83693	HGNCID:	16475	Length:	330	Species:	Homo sapiens

Alignment Length:	303	Identity:	124/303 - (40%)
Similarity:	187/303 - (61%)	Gaps:	5/303 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLSIVAYLYENLKSLFSI--IKSVVEPFFRPNLPK--TLAEKFGNWAVVTGATDGIGKEYARELA 77
            :|::|...|...||:..|  ..|::...|.|.|..  .|.:::|.||||:||||||||.||.|||
Human    24 ALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELA 88

  Fly    78 RQGLNLVLVSRKEEKLIAVTNEIGSQYNVKIKWIVADFAKGREVYAHIEKELNGIEVGILVNNVG 142
            .:|||::|:||.||||..|..:|...|.|:...|||||:.|||:|..|.:.|...:|||||||||
Human    89 SRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGILVNNVG 153

  Fly   143 TIHD-PESLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMISRRKGAIVNLGSSSELQPHPNLTAY 206
            ..:. |:...::|||.|||::.||:.:.:::...:||.|:.|:|||||.:.|.|..:|.|.|.|:
Human   154 VFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAF 218

  Fly   207 AATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKVRQGGLLFPNAYSYARSAVFTL 271
            :|:|.::.||::.|:||.|...|.||.::|.:|||:|.:.|:.:.:...|.|:...||..||.||
Human   219 SASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTL 283

  Fly   272 GKTSETNGFWVHGLQYAFMKLAPMDIRTYFGYQLFKRMRIEAM 314
            |.:..|.|:|.|.:|:.|.:..|..:..:....|.:.:|.||:
Human   284 GISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEAL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31810	NP_724023.1	PLN02780	12..310	CDD:166421	121/297 (41%)
CG31810	NP_724023.1	17beta-HSD1_like_SDR_c	56..297	CDD:187614	109/241 (45%)
HSDL1	NP_113651.4	Required for mitochondria translocation	2..82		23/57 (40%)
HSDL1	NP_113651.4	17beta-HSD1_like_SDR_c	67..309	CDD:187614	109/241 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141586
Domainoid	1	1.000	189	1.000	Domainoid score	I3291
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100660
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3445
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		otm40861
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17415
SonicParanoid	1	1.000	-	-		X3003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700