Protein Alignment CG31810 and HSD17B12

DIOPT Version :10

• Sequence 1: NP_724023.1
• Gene: CG31810 / 318955
• FlyBaseID: FBgn0051810
• Length: 324
• Species: Drosophila melanogaster
• Sequence 2: NP_057226.1
• Gene: HSD17B12 / 51144
• HGNCID: 18646
• Length: 312
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 122/324 - (37%)
• Similarity: 181/324 - (55%)
• Gaps: 37/324 - (11%)

  Fly    12 IYIVGSLSIVAYLYENLK-SLFSIIKSVV-----EPFFRPNLPKTLAEKFGNWAVVTGATDGIGK 70
            :|.||: ..||||...:. |||:.::  |     |....|.|        |.||||||:||||||
Human    11 LYWVGA-GTVAYLALRISYSLFTALR--VWGVGNEAGVGPGL--------GEWAVVTGSTDGIGK 64

  Fly    71 EYARELARQGLNLVLVSRKEEKLIAVTNEIGSQYNVKIKWIVADFAKGREVYAHIEKELNGIEVG 135
            .||.|||:.|:.:||:||.::||..|::||..::.|:.:.|..||| ..::|..|:..|.|:|:|
Human    65 SYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFA-SEDIYDKIKTGLAGLEIG 128

  Fly   136 ILVNNVGTIHD-PE------SLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMISRRKGAIVNLGS 193
            |||||||..:: ||      .||.|.:.|    :.:|:.||..:|:.:||.|:.|.||||:|:.|
Human   129 ILVNNVGMSYEYPEYFLDVPDLDNVIKKM----ININILSVCKMTQLVLPGMVERSKGAILNISS 189

  Fly   194 SSELQPHPNLTAYAATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKVRQGGLLFP 258
            .|.:.|.|.||.|:|||.||..|::.|..|.....:.||.|:|.||||.:    .|:|:..|..|
Human   190 GSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKL----AKIRKPTLDKP 250

  Fly   259 NAYSYARSAVFTLGKTSETNGFWVHGLQYAFMKLAPMDIRTYFGYQLFKRMRIEAMEHRLKNQK 322
            :..::.:||:.|:|..|.|||:.:|.|..:.:...|    ::...::...|......|.||..|
Human   251 SPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLP----SWIYLKIVMNMNKSTRAHYLKKTK 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31810	NP_724023.1	17beta-HSD1_like_SDR_c	56..297	CDD:187614	103/247 (42%)
HSD17B12	NP_057226.1	17beta-HSD1_like_SDR_c	50..289	CDD:187614	103/251 (41%)
		Di-lysine motif	308..312		1/3 (33%)