DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31810 and hsd17b12a

DIOPT Version :9

Sequence 1:	NP_724023.1	Gene:	CG31810 / 318955	FlyBaseID:	FBgn0051810	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_957175.1	Gene:	hsd17b12a / 327417	ZFINID:	ZDB-GENE-030131-5628	Length:	319	Species:	Danio rerio

Alignment Length:	321	Identity:	125/321 - (38%)
Similarity:	184/321 - (57%)	Gaps:	36/321 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQVISTGIYIVGSLSIVAYLYENLKSLFSIIKSVVEPFFR------PNLPKTLAEKFGNWAVVTG 63
            ||.....::.||:| |.|.|     :|:.:.|::..  ||      .:|   |:.|.|.||||||
Zfish    10 LQPAERALFWVGAL-ITASL-----ALYVVYKTITG--FRIWVLGNGDL---LSPKLGKWAVVTG 63

  Fly    64 ATDGIGKEYARELARQGLNLVLVSRKEEKLIAVTNEIGSQYNVKIKWIVADFAKGREVYAHIEKE 128
            |||||||.||.||||:|.:::|:||.:|||..|...:.|.|.|:.|.|..||:: .:||..|||.
Zfish    64 ATDGIGKSYAEELARRGFSMMLISRSQEKLDDVAKSLESTYKVETKTIAVDFSQ-IDVYPKIEKG 127

  Fly   129 LNGIEVGILVNNVGT--------IHDPESLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMISRRK 185
            |.|:|:||||||||.        :|.|:     .|:.:..::.||:.||..:||.:||:|.:|.|
Zfish   128 LAGLEIGILVNNVGISYSYPEFFLHIPD-----LENFITTMINVNITSVCQMTRLVLPRMEARAK 187

  Fly   186 GAIVNLGSSSELQPHPNLTAYAATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKV 250
            |.|:|:.|:|.:.|.|.||.|::||.||..|::||:.|.....|.:|.|:|.||||.|.    |:
Zfish   188 GVILNISSASGMFPVPLLTIYSSTKAFVDFFSRGLQTEYKCKGIIIQSVLPFFVATKMT----KI 248

  Fly   251 RQGGLLFPNAYSYARSAVFTLGKTSETNGFWVHGLQ-YAFMKLAPMDIRTYFGYQLFKRMR 310
            |:..|..|....|..:.:.|:|...:|||::.|.:. :....|||:|:....|.::.|..|
Zfish   249 RKPTLDKPTPERYVAAELNTVGLQDQTNGYFPHAVMGWVTTILAPIDLVLNLGLRMNKAQR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31810	NP_724023.1	PLN02780	12..310	CDD:166421	122/312 (39%)
CG31810	NP_724023.1	17beta-HSD1_like_SDR_c	56..297	CDD:187614	106/249 (43%)
hsd17b12a	NP_957175.1	PLN02780	18..310	CDD:166421	123/313 (39%)
hsd17b12a	NP_957175.1	17beta-HSD1_like_SDR_c	56..288	CDD:187614	103/241 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730