DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31809 and Hsdl1

DIOPT Version :9

Sequence 1:	NP_001097168.1	Gene:	CG31809 / 318954	FlyBaseID:	FBgn0051809	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001365945.1	Gene:	Hsdl1 / 72552	MGIID:	1919802	Length:	330	Species:	Mus musculus

Alignment Length:	303	Identity:	115/303 - (37%)
Similarity:	183/303 - (60%)	Gaps:	5/303 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLSIAAFLYENLKSLFSI--IKSVVEPFFRPNLPK--TLAEKFGNWAVVTGATDGIGKEYARELA 69
            :|::....|...||:..|  ..|:|...|.|.|..  .|.:::|.|||::||||||||.||.|||
Mouse    24 ALALVGAWYTARKSITVICDFYSLVRLHFIPRLGSRPDLIKQYGRWAVISGATDGIGKAYAEELA 88

  Fly    70 RQGLNLVLVSRKEEKLIAVTNEIGSQYNVKIKWIVADFAKGREVYAHIEKELNGIEVGILVNNVG 134
            ..|||::|:|::||||.|....|...|.|:...:||||::|||:||.|.:.|...::|||||:||
Mouse    89 SHGLNVILISQEEEKLQAAAKHIADTYRVETLVLVADFSRGREIYAPIREALRDRDIGILVNDVG 153

  Fly   135 TIHD-PESLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMISRRKGAIVNLGSSSELQPHPNLTAY 198
            ..:. |:...:|.||.|||::.||:.:.:::...:||.|:.|:|||||.:.|.|..:|.|.|.|:
Mouse   154 AFYPYPQYFSQVPEDTLWDIVNVNIAAASLMVHIVLPGMVERKKGAIVTVSSGSCCKPTPQLAAF 218

  Fly   199 AATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKVRQGGLLFPNAYSYARSAVFTL 263
            :|:|.::.||::.|:||.|...|.||.::|.:|.::..:.:..:.:...|.|:...||:.||.||
Mouse   219 SASKAYLDHFSRALQYEYASKGIFVQSLIPFYVTSSGAAPASFLHRCPWLAPSPRVYAQHAVSTL 283

  Fly   264 GKTSETNGFWVHGLQYALMKLFPMEIRTYFVYQLFKRMRIEAM 306
            |.:..|.|:|.|.:|:...:..|..:..:....|.:.:|.||:
Mouse   284 GISKRTTGYWSHSIQFLFAQYMPEWLWVWGANLLNRSLRKEAL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31809	NP_001097168.1	17beta-HSD1_like_SDR_c	48..286	CDD:187614	99/238 (42%)
CG31809	NP_001097168.1	DltE	50..302	CDD:223377	100/252 (40%)
Hsdl1	NP_001365945.1	Required for mitochondria translocation. /evidence=ECO:0000250	2..82		22/57 (39%)
Hsdl1	NP_001365945.1	17beta-HSD1_like_SDR_c	67..309	CDD:187614	100/241 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831535
Domainoid	1	1.000	178	1.000	Domainoid score	I3537
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100660
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3584
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		otm42934
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2822
SonicParanoid	1	1.000	-	-		X3003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.700