Protein Alignment CG31809 and HSD17B12

DIOPT Version :9

• Sequence 1: NP_001097168.1
• Gene: CG31809 / 318954
• FlyBaseID: FBgn0051809
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_057226.1
• Gene: HSD17B12 / 51144
• HGNCID: 18646
• Length: 312
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 121/323 - (37%)
• Similarity: 181/323 - (56%)
• Gaps: 31/323 - (9%)

  Fly     2 GLIYIVGSLSIAAFLYENLKSLFSIIKSVV-----EPFFRPNLPKTLAEKFGNWAVVTGATDGIG 61
            |.:|.||:.::|........|||:.::  |     |....|.|        |.||||||:|||||
Human     9 GFLYWVGAGTVAYLALRISYSLFTALR--VWGVGNEAGVGPGL--------GEWAVVTGSTDGIG 63

  Fly    62 KEYARELARQGLNLVLVSRKEEKLIAVTNEIGSQYNVKIKWIVADFAKGREVYAHIEKELNGIEV 126
            |.||.|||:.|:.:||:||.::||..|::||..::.|:.:.|..||| ..::|..|:..|.|:|:
Human    64 KSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFA-SEDIYDKIKTGLAGLEI 127

  Fly   127 GILVNNVGTIHD-PE------SLDKVSEDMLWDLLTVNVGSVTMLTRKILPQMISRRKGAIVNLG 184
            ||||||||..:: ||      .||.|.:.|    :.:|:.||..:|:.:||.|:.|.||||:|:.
Human   128 GILVNNVGMSYEYPEYFLDVPDLDNVIKKM----ININILSVCKMTQLVLPGMVERSKGAILNIS 188

  Fly   185 SSSELQPHPNLTAYAATKKFVTHFTKGLEYEVAEHNIHVQLVMPAFVATNMNSYSDKVRQGGLLF 249
            |.|.:.|.|.||.|:|||.||..|::.|..|.....:.||.|:|.||||.:    .|:|:..|..
Human   189 SGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKL----AKIRKPTLDK 249

  Fly   250 PNAYSYARSAVFTLGKTSETNGFWVHGLQYALMKLFPMEIRTYFVYQLFKRMRIEAMEHRLKN 312
            |:..::.:||:.|:|..|.|||:.:|.|..:::...|..|....|..:.|..|...::...||
Human   250 PSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31809	NP_001097168.1	17beta-HSD1_like_SDR_c	48..286	CDD:187614	102/244 (42%)
		DltE	50..302	CDD:223377	105/258 (41%)
HSD17B12	NP_057226.1	NADB_Rossmann	<3..>83	CDD:304358	34/83 (41%)
		DltE	50..300	CDD:223377	105/258 (41%)
		17beta-HSD1_like_SDR_c	50..289	CDD:187614	103/247 (42%)
		Di-lysine motif	308..312		0/3 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.803099	Normalized mean entropy	S1433
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680