DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31787 and TMED10

DIOPT Version :10

Sequence 1:NP_724105.1 Gene:CG31787 / 318941 FlyBaseID:FBgn0051787 Length:232 Species:Drosophila melanogaster
Sequence 2:NP_006818.3 Gene:TMED10 / 10972 HGNCID:16998 Length:219 Species:Homo sapiens


Alignment Length:31 Identity:11/31 - (35%)
Similarity:15/31 - (48%) Gaps:2/31 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 LTLTPEIIIVDTPAAAVAKPFQ--GTPNACG 212
            :.|.|.::|.:...|..|.|.|  ||...||
Human    22 INLGPVMLISEEQPAQPALPIQPEGTRVVCG 52

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31787NP_724105.1 EMP24_GP25L 31..220 CDD:426051 11/31 (35%)
TMED10NP_006818.3 Required for interaction with STX17. /evidence=ECO:0000269|PubMed:21545355 1..142 11/31 (35%)
EMP24_GP25L 31..213 CDD:426051 8/22 (36%)
Required for TMED10 and TMED2 cis-Golgi network localization 147..178
Interaction with COPG1 204..219
Interaction with ARF1 and IL1B. /evidence=ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:32272059 207..219
COPI vesicle coat-binding 211..219
COPII vesicle coat-binding 211..212
Blue background indicates that the domain is not in the aligned region.

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