DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31787 and TMED2

DIOPT Version :9

Sequence 1:	NP_724105.1	Gene:	CG31787 / 318941	FlyBaseID:	FBgn0051787	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001308374.1	Gene:	TMED2 / 10959	HGNCID:	16996	Length:	208	Species:	Homo sapiens

Alignment Length:	213	Identity:	49/213 - (23%)
Similarity:	103/213 - (48%)	Gaps:	11/213 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VIWLLQLLLLLDLKFSNAEPHNKQLTVFAEAGRQECFYQPIATTENIKIDYQVIHGGLGETHINF 71
            ::.|.:||:||....:....:    .|..:|..:|||::.:.:...:.:.::|..||.  ..|:.
Human     1 MVTLAELLVLLAALLATVSGY----FVSIDAHAEECFFERVTSGTKMGLIFEVAEGGF--LDIDV 59

  Fly    72 NLMDPSRRLLIAETKRQMGKHSIQANETGSYKFCFDNTISTFNQKIVSFTLEVAPADREERELRD 136
            .:..|..:.:....:...||::..|:..|:|||||.|.:||...|||.||:::..|.:.:    |
Human    60 EITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQ----D 120

  Fly   137 LRQEMLTDYHFDVAYTGIDSYVGKIHVNLMRSRQTQDFIRAIEARDRNVAESTYSMVNKWSWAQF 201
            :..|...| .:|.....::..:.::.|.:...:..|:::...|...|.:.::|.|.|..||:.:.
Human   121 METEGGGD-TWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEA 184

  Fly   202 LSMIFVGFLQVLMVRSIF 219
            |.::.:...|:..::..|
Human   185 LVLVAMTLGQIYYLKRFF 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31787	NP_724105.1	EMP24_GP25L	30..220	CDD:279450	44/190 (23%)
TMED2	NP_001308374.1	EMP24_GP25L	23..203	CDD:366467	44/187 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910