DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31787 and TMED7-TICAM2

DIOPT Version :9

Sequence 1:	NP_724105.1	Gene:	CG31787 / 318941	FlyBaseID:	FBgn0051787	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001157940.1	Gene:	TMED7-TICAM2 / 100302736	HGNCID:	33945	Length:	404	Species:	Homo sapiens

Alignment Length:	190	Identity:	57/190 - (30%)
Similarity:	82/190 - (43%)	Gaps:	24/190 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLQLLLLLDLKFSNAEPHNKQLTVFAEAGRQECFYQPIATTENIKIDYQVIHGGLGETHINFNLM 74
            ||.||||:......:|     :|.......::|||:.||......:::|||.|  |...::..|.
Human    21 LLALLLLVPGPGGASE-----ITFELPDNAKQCFYEDIAQGTKCTLEFQVITG--GHYDVDCRLE 78

  Fly    75 DPSRRLLIAETKRQMGKHSIQANETGSYKFCFDNTISTFNQKIVSFTLEVA---PADREERELRD 136
            ||..::|..|.|:|....:..|::.|:|||||.|..|||..|.|.|..:|.   |....|..:.
Human    79 DPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVS- 142

  Fly   137 LRQEMLTDYHFDVAYTGIDSYVGKIHVNLMRSRQTQDFIRAIEARDRNVAESTYSMVNKW 196
                         |.|.::|....||..|......|...|..||:.|:.||...:.|..|
Human   143 -------------ALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYW 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31787	NP_724105.1	EMP24_GP25L	30..220	CDD:279450	50/170 (29%)
TMED7-TICAM2	NP_001157940.1	EMP24_GP25L	36..189	CDD:279450	50/173 (29%)
TMED7-TICAM2	NP_001157940.1	TIR_2	250..>341	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000272
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103696
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1790
SonicParanoid	1	1.000	-	-		X1789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740