DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and Prss12

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_445956.1	Gene:	Prss12 / 85266	RGDID:	69238	Length:	761	Species:	Rattus norvegicus

Alignment Length:	250	Identity:	72/250 - (28%)
Similarity:	117/250 - (46%)	Gaps:	39/250 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 PWMVALL------DARTSSYVAGGALIAPHVVITARQ---RTENMTASQLVVRAGEWDFSTKTEQ 174
            ||..:|.      |.|   .:.|..|::...|:||..   |..|.:.| ..||.|  |:.|...:
  Rat   529 PWQASLRLKSTHGDGR---LLCGATLLSSCWVLTAAHCFTRYGNNSRS-YAVRVG--DYHTLVPE 587

  Fly   175 LPSVDVPIRSIVRHPGFNLENGANNVALVFLRRS----LTSSRHINPICMP---SAPKNFDFSRC 232
            ....|:.::.||.|..:..::...::|||.|:.|    ...|.|:.|.|:|   ..|:. ..|.|
  Rat   588 GFEQDIGVQQIVIHRNYRPDSSDYDIALVRLQGSGEQCARLSTHVLPACLPLWRERPQK-TASNC 651

  Fly   233 IFTGWGKNSFDDPSYMNVLKKISLPVVQRRTCEQQLR-LYYGNDFELDNSLMCAGG--EPGK-DS 293
            ..||||...   .:|...|::.::|::.:|.|:::.: |:.|.       ::|||.  |..: ||
  Rat   652 HITGWGDTG---RAYSRTLQQAAVPLLPKRFCKERYKGLFTGR-------MLCAGNLQEDNRVDS 706

  Fly   294 CEGDGGSPLACAIKDNPQRYELAGIVNFGVDCGLPGVPAVYTNVANVIEWITLTT 348
            |:||.|.||.|...|  :.:.:.|:.::|..||:...|.|||.|...:.||...|
  Rat   707 CQGDSGGPLMCEKPD--ETWVVYGVTSWGYGCGIKDTPGVYTRVPAFVPWIKSVT 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	69/244 (28%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	69/244 (28%)
Prss12	NP_445956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..89
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..266	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	391..485	CDD:278931
		Zymogen activation region. /evidence=ECO:0000250	505..516
		Tryp_SPc	516..755	CDD:214473	69/244 (28%)
		Tryp_SPc	517..758	CDD:238113	71/247 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910