DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	372	Identity:	91/372 - (24%)
Similarity:	148/372 - (39%)	Gaps:	82/372 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQAQGQNAELNQSCGASNEHQCV---PRHMCKVKIEFRMAMTYRNLGCVS---TAICCPKNLII- 77
            |:..||||.|.....||.:..|.   ..|             |.|:.|..   .:.....||.:
Human   108 VRVGGQNAVLQVFTAASWKTMCSDDWKGH-------------YANVACAQLGFPSYVSSDNLRVS 159

  Fly    78 ------KEPRLIINEPITDPQ--------------------------CGFVNSKGVTFSFREEDT 110
                  :|..:.|:..:.|.:                          ||  :.:|  :|.|....
Human   160 SLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACG--HRRG--YSSRIVGG 220

  Fly   111 GLAQEAEVPWMVALLDARTSSY-VAGGALIAPHVVITARQRTENMTASQLVVRAGEWDFSTKTEQ 174
            .::..::.||..:|   :...| :.||::|.|..:|||.....::...:      .|........
Human   221 NMSLLSQWPWQASL---QFQGYHLCGGSVITPLWIITAAHCVYDLYLPK------SWTIQVGLVS 276

  Fly   175 L---PSVDVPIRSIVRHPGFNLENGANNVALVFLRRSLTSSRHINPICMPSAPKNF-DFSRCIFT 235
            |   |:....:..||.|..:..:...|::||:.|...||.:..|.|:|:|::.:|| |...|..:
Human   277 LLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTS 341

  Fly   236 GWGKNSFDDPSYMNVLKKISLPVVQRRTCEQQLRLYYGNDFELDNSLMCAG---GEPGKDSCEGD 297
            |||...........||...::|::..:.|..  |..||.  .:..|::|||   |  |.|||:||
Human   342 GWGATEDGAGDASPVLNHAAVPLISNKICNH--RDVYGG--IISPSMLCAGYLTG--GVDSCQGD 400

  Fly   298 GGSPLACAIKDNPQRYELAGIVNFGVDCGLPGVPAVYTNVANVIEWI 344
            .|.||.|   ...:.::|.|..:||:.|.....|.|||.|.:.::||
Human   401 SGGPLVC---QERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	66/238 (28%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	66/238 (28%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	19/112 (17%)
		Tryp_SPc	216..444	CDD:214473	67/245 (27%)
		Tryp_SPc	217..447	CDD:238113	68/246 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910