DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and PRSS56

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	355	Identity:	95/355 - (26%)
Similarity:	148/355 - (41%)	Gaps:	73/355 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PRLIINEPITDPQCG--FVNSKGVTFSF-REEDTGLAQEAEVPWMVAL-LDARTSSYVAGGALIA 140
            |:.::.:|.....||  ..::..||.:. |......|.....||:|.| |..:.   :.||.|:|
Human    75 PQALLQDPPEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQP---LCGGVLVA 136

  Fly   141 PHVVITARQRTENMTASQLVVRAGE--WDFS----TKTEQLPSVDVPIRSIVRHPGFNLENGANN 199
            ...|:||        |...|....|  |..:    ::.||  :.:||:..|:.||.|:.....|:
Human   137 ASWVLTA--------AHCFVGAPNELLWTVTLAEGSRGEQ--AEEVPVNRILPHPKFDPRTFHND 191

  Fly   200 VALVFLRRSLTSSRHINPICMPSAPKNFDF-SRCIFTGWGKNSFDDPSYMNVLKKISLPVVQRRT 263
            :|||.|...::......|:|:|..|:.... :.|...|||. .|:|......:::..:|::...|
Human   192 LALVQLWTPVSPGGSARPVCLPQEPQEPPAGTACAIAGWGA-LFEDGPEAEAVREARVPLLSTDT 255

  Fly   264 CEQQLRLYYGNDFELDNSLMCAG---GEPGKDSCEGDGGSPLACAIKDNPQRYELAGIVNFGVDC 325
            |.:.|    |.... .::::|||   |  |.|||:||.|.||.|:......|..|.|:.::|..|
Human   256 CRRAL----GPGLR-PSTMLCAGYLAG--GVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGC 313

  Fly   326 GLPGVPAVYTNVANVIEWITLTTVNMPLPEEREEVPYASPTLSAGPYLNQ---WNQPNYEWLPTG 387
            |.||.|.|||.||...:|:            :|::..||.  |..|...:   |:.|
Human   314 GEPGKPGVYTRVAVFKDWL------------QEQMSAASS--SREPSCRELLAWDPP-------- 356

  Fly   388 YPNVNSIPWQLQEANNDLAN--SQYVRYYP 415
                       ||...|.|.  :.|.|..|
Human   357 -----------QELQADAARLCAFYARLCP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	73/241 (30%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	73/241 (30%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		4/20 (20%)
		Tryp_SPc	105..335	CDD:238113	74/262 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910