DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and PRSS1

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	237	Identity:	70/237 - (29%)
Similarity:	117/237 - (49%)	Gaps:	28/237 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 QEAEVPWMVALLDARTSSYVAGGALIAPHVVITARQRTENMTASQLVVRAGEWDFST--KTEQLP 176
            :|..||:.|:|   .:..:..||:||....|::|    .:...|::.||.||.:...  ..||.
Human   256 EENSVPYQVSL---NSGYHFCGGSLINEQWVVSA----GHCYKSRIQVRLGEHNIEVLEGNEQF- 312

  Fly   177 SVDVPIRSIVRHPGFNLENGANNVALVFLRRSLTSSRHINPICMPSAPKNFDFSRCIFTGWGKNS 241
               :....|:|||.::.:...|::.|:.|......:..::.|.:|:||.... ::|:.:|||..:
Human   313 ---INAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATG-TKCLISGWGNTA 373

  Fly   242 FDDPSYMNVLKKISLPVVQRRTCEQQLRLYYGNDFELDNSLMCAGG-EPGKDSCEGDGGSPLACA 305
            .....|.:.|:.:..||:.:..||..   |.|   ::.:::.|.|. |.|||||:||.|.|:.|
Human   374 SSGADYPDELQCLDAPVLSQAKCEAS---YPG---KITSNMFCVGFLEGGKDSCQGDSGGPVVC- 431

  Fly   306 IKDNPQRYELAGIVNFGVDCGLPGVPAVYTNVANVIEWITLT 347
               |.|   |.|:|::|..|.....|.|||.|.|.::||..|
Human   432 ---NGQ---LQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNT 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	67/232 (29%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	67/232 (29%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	67/232 (29%)
		Tryp_SPc	249..467	CDD:238113	69/235 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910