DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and C1s1

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001091086.1	Gene:	C1s1 / 50908	MGIID:	1355312	Length:	694	Species:	Mus musculus

Alignment Length:	307	Identity:	84/307 - (27%)
Similarity:	133/307 - (43%)	Gaps:	47/307 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 YRNLGCVSTAICCPKNLIIKEPRLIINEPITDPQCGFVNSKGVTFSFREEDTGLAQEAEV---PW 120
            ||   |.:........|.|:.||.|       |.||....   .|...:...| .|.|::   ||
Mouse   407 YR---CAANGRWVNDQLGIELPRCI-------PACGVPTE---PFQVHQRIFG-GQPAKIENFPW 457

  Fly   121 MVALLDARTSSYVAGGALIAPHVVITARQRTENMTASQLVVRAGEWDFSTKTEQLPSVD-VPIRS 184
            .|.....|     |.||||..:.|:||....|.::...:.|..    .|.:|..|.:.. :..:.
Mouse   458 QVFFNHPR-----ASGALINEYWVLTAAHVLEKISDPLMYVGT----MSVRTTLLENAQRLYSKR 513

  Fly   185 IVRHPGFNLE-------NGANNVALVFLRRSLTSSRHINPICMPSAPKNFDFS---RCIFTGWGK 239
            :..||.:..|       |..|::|||.|:..:.....::|||:|.....::.|   ..:.:|||
Mouse   514 VFIHPSWKKEDDPNTRTNFDNDIALVQLKDPVKMGPKVSPICLPGTSSEYNVSPGDMGLISGWG- 577

  Fly   240 NSFDDPSYMNVLKKISLPVVQRRTCEQ---QLRLYYGNDFELDNSLMCAGGEPGKDSCEGDGGSP 301
             |.:...::..|:...:||....||:|   :.......|:...::::|| ||.|.|||.||.|..
Mouse   578 -STEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDNMICA-GEKGVDSCHGDSGGA 640

  Fly   302 LACAIKD-NPQRYELAGIVNFGVDCGLPGVPAVYTNVANVIEWITLT 347
            .|..:.: ...::.:||:|::|..||..|   |||.|.|.::||..|
Mouse   641 FAFQVPNVTVPKFYVAGLVSWGKRCGTYG---VYTKVKNYVDWILKT 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	68/248 (27%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	68/248 (27%)
C1s1	NP_001091086.1	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:373209
		CUB	181..293	CDD:366096
		CCP	307..361	CDD:153056
		CCP	365..428	CDD:153056	7/23 (30%)
		Tryp_SPc	443..681	CDD:214473	69/253 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910