DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and ACR

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001088.2	Gene:	ACR / 49	HGNCID:	126	Length:	421	Species:	Homo sapiens

Alignment Length:	355	Identity:	91/355 - (25%)
Similarity:	142/355 - (40%)	Gaps:	54/355 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TAICCPKNLIIKEPRLIINEPIT-DPQCGFVNSKGVTFSFREEDTG--------LAQEAEVPWMV 122
            |||     |::....::..:..| |..||        ..||:...|        .||....||||
Human     7 TAI-----LLVLAVSVVAKDNATCDGPCG--------LRFRQNPQGGVRIVGGKAAQHGAWPWMV 58

  Fly   123 ALLDARTSS---YVAGGALIAPHVVITARQ---RTENMTASQLVVRAGEWDF-STKTEQLPSVDV 180
            :|.....:|   :..||:|:....|:||..   ...|:...:||..|.|..: :.|..:.|..:.
Human    59 SLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQER 123

  Fly   181 PIRSIVRHPGFNLENGANNVALVFLRRSLTSSRHINPICMP----SAPKNFDFSRCIFTGWGKNS 241
            .:..|:.|..:|.....|::|||.:...::..|.|.|.|:|    ..|:.  ...|...|||...
Human   124 YVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRG--SQSCWVAGWGYIE 186

  Fly   242 FDDPSYMNVLKKISLPVVQRRTCEQQLRLYYGNDFELDNSLMCAGGEPGK-DSCEGDGGSPLACA 305
            ...|...::|.:..:.::....|..  ..:|....:..|  :|||...|| |:|:||.|.||.|
Human   187 EKAPRPSSILMEARVDLIDLDLCNS--TQWYNGRVQPTN--VCAGYPVGKIDTCQGDSGGPLMC- 246

  Fly   306 IKDNPQ-RYELAGIVNFGVDCGLPGVPAVYTNVANVIEWITLTTVNMPLPEEREEVPYASPTLSA 369
             ||:.: .|.:.||.::||.|.....|.:||.....:.||.....:..|...:...| ..||...
Human   247 -KDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATP-PPPTTRP 309

  Fly   370 GPYLNQWNQPNYEWLPTGYPNVNSIPWQLQ 399
            .|.     :|     |..:|....:||..|
Human   310 PPI-----RP-----PFSHPISAHLPWYFQ 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	67/243 (28%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	67/243 (28%)
ACR	NP_001088.2	Tryp_SPc	42..285	CDD:214473	67/250 (27%)
		Tryp_SPc	43..288	CDD:238113	69/252 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..316		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..383		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910