DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31780 and AGRN

DIOPT Version :9

Sequence 1:NP_723920.1 Gene:CG31780 / 318937 FlyBaseID:FBgn0051780 Length:464 Species:Drosophila melanogaster
Sequence 2:NP_001292204.1 Gene:AGRN / 375790 HGNCID:329 Length:2068 Species:Homo sapiens


Alignment Length:340 Identity:80/340 - (23%)
Similarity:107/340 - (31%) Gaps:120/340 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 VKIEFRMAMTYRNLGCVSTAICCPKNLIIKEPRLIINEPITDPQCGFVNSKGVTFSFREEDTGLA 113
            ||.:|| ::..|:||        |.    |..|.|::... ||          |.:||..|...|
Human  1182 VKKDFR-SVRLRDLG--------PG----KSVRAIVDVHF-DP----------TTAFRAPDVARA 1222

  Fly   114 -------------------QE----AEVPWMVALLDARTSSYVAGGALIAPHVVITARQRTENMT 155
                               ||    .:..|..|.:...||..:|.||        |||       
Human  1223 LLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGA--------TAR------- 1272

  Fly   156 ASQLVVRAGEWDFSTKTEQLPSVDVPIRSIVRHPGFNLENGANNVALVFLRRSLTSSRHINPICM 220
                         :|...:|||..|..|:  .||....:..|...|....||..|::....|...
Human  1273 -------------ATTASRLPSSAVTPRA--PHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRR 1322

  Fly   221 PSA----PKNFDFSRCIFTG----W---GKNSFDDPSYMN--VLKKI---SLPVVQRRT--CEQQ 267
            |.|    ||..|...|...|    |   |..:...|:...  |.:|:   .:|..:.|:  ....
Human  1323 PPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPT 1387

  Fly   268 LRLYYG-------NDFELDNSLMCAGGEPGKDSCEGDGGSPLACAIKDNPQRYELAGIVNFGVDC 325
            ||.|:.       ...|....|:..|...|||.        ||.|:.|        |.|....|.
Human  1388 LRAYHTLRLALEFRALEPQGLLLYNGNARGKDF--------LALALLD--------GRVQLRFDT 1436

  Fly   326 GLPGVPAVYTNVANV 340
            |  ..|||.|:...|
Human  1437 G--SGPAVLTSAVPV 1449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31780NP_723920.1 Tryp_SPc 113..344 CDD:214473 63/276 (23%)
Tryp_SPc 113..344 CDD:238113 63/276 (23%)
AGRNNP_001292204.1 NtA 44..146 CDD:308653
KAZAL 196..242 CDD:197624
KAZAL 272..317 CDD:197624
KAZAL_FS 349..389 CDD:320757
KAZAL_FS 421..461 CDD:238052
KAZAL 489..534 CDD:197624
KAZAL 554..599 CDD:197624
KAZAL 619..664 CDD:197624
KAZAL 704..750 CDD:197624
Laminin_EGF 793..835 CDD:278482
Laminin_EGF 847..>883 CDD:278482
KAZAL 922..969 CDD:197624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 995..1096
SEA 1130..1254 CDD:214554 21/95 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1334 17/58 (29%)
EGF 1333..1363 CDD:306513 6/29 (21%)
Laminin_G_1 1400..1531 CDD:278483 19/68 (28%)
EGF_CA 1555..1585 CDD:238011
Laminin_G_1 1668..1803 CDD:278483
EGF_CA 1825..1857 CDD:238011
Laminin_G_1 1921..2051 CDD:278483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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