DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31780 and PRSS36

DIOPT Version :9

Sequence 1:	NP_723920.1	Gene:	CG31780 / 318937	FlyBaseID:	FBgn0051780	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	314	Identity:	88/314 - (28%)
Similarity:	130/314 - (41%)	Gaps:	65/314 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AQEAEVPWMVALLDARTSSYVAGGALIAPHVVITARQRTENMTASQLVVRAGEWDF--------- 168
            ||....||.|:|  .....::.||:||||..|::|....  ||...| ..|.||..
Human    53 AQPGTWPWQVSL--HHGGGHICGGSLIAPSWVLSAAHCF--MTNGTL-EPAAEWSVLLGVHSQDG 112

  Fly   169 ---STKTEQLPSVDVPIRSIVRHPGFNLENGANNVALVFLRRSLTSSRHINPICMPSAPKNF-DF 229
               ...|..:.::.||...      ..:|.|| ::||:.|....:....:.|:|:|.|...| ..
Human   113 PLDGAHTRAVAAIVVPANY------SQVELGA-DLALLRLASPASLGPAVWPVCLPRASHRFVHG 170

  Fly   230 SRCIFTGWGKNSFDDPSYMN-VLKKISLPVVQRRTCEQQLRLY-----YGNDFELDNSLMCAGGE 288
            :.|..||||.....||..:. ||:::.|.::...||:   .||     :....::...::|||..
Human   171 TACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQ---CLYSQPGPFNLTLQILPGMLCAGYP 232

  Fly   289 PG-KDSCEGDGGSPLACAIKDNPQRYELAGIVNFGVDCGLPGVPAVYTNVANVIEWITLTTVNMP 352
            .| :|:|:||.|.||.|   :...|:..|||.:||..||....|.|:|.||....||
Human   233 EGRRDTCQGDSGGPLVC---EEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWI-------- 286

  Fly   353 LPEEREEVPYASPTLSAGPYLNQWNQPNYEWLPTGYPNVNSIPWQLQEANNDLA 406
                ||:|..:.|    ||.           .||......|.|.:.:|.|..:|
Human   287 ----REQVMGSEP----GPA-----------FPTQPQKTQSDPQEPREENCTIA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:214473	73/250 (29%)
CG31780	NP_723920.1	Tryp_SPc	113..344	CDD:238113	73/250 (29%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	73/250 (29%)
		Tryp_SPc	47..289	CDD:238113	76/265 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		7/38 (18%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910